LEADER 03413nam 22006375 450 001 9910416100203321 005 20251113203101.0 010 $a3-030-51747-0 024 7 $a10.1007/978-3-030-51747-2 035 $a(CKB)4100000011389968 035 $a(DE-He213)978-3-030-51747-2 035 $a(MiAaPQ)EBC6308684 035 $a(PPN)250214903 035 $a(EXLCZ)994100000011389968 100 $a20200817d2020 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aInducible Lymphoid Organs /$fedited by Kenji Kabashima, Gyohei Egawa 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (VII, 160 p. 1 illus.) 225 1 $aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v426 311 08$a3-030-51746-2 320 $aIncludes bibliographical references. 327 $aBasics of Inducible Lymphoid Organs -- Role of iBALT in respiratory immunity -- Chronic inflammation in mucosal tissues: Barrier integrity, inducible lymphoid tissues, and immune surveillance -- Role of lymphoid structure in skin immunity -- Memory lymphocyte clusters in genital immunity: Role of tissue-resident memory T cells (TRM) -- Ectopic lymphoid tissue in Rheumatoid Arthritis -- Artificial construction of immune tissues/organoids and their application for immunological intervention. 330 $aThis book sheds new light on ?inducible? lymphoid organs (ILOs): antigen presentation sites that are generated de novo in peripheral tissues under various pathogenic conditions. Accomplished immunologists demonstrate that the physiological role of these ILOs is completely different from that of central lymphoid organs, i.e., the lymph nodes or spleen. In addition to the central organs, the ILOs are considered essential structures for the efficient elicitation of adaptive immune responses in lesions. The respective chapters highlight examples from multiple sites, e.g. the skin, lung, intestinal tract, genital tract, the synovial membrane of the joints and artificial lymph nodes. Accordingly, readers will learn that ILO structure and function can vary substantially, depending on the context. Presenting the results of the latest immunological research, the book offers a fascinating and insightful read for both scientists and clinicians in the areas of infectious and immune-associated diseases. 410 0$aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v426 606 $aImmunology 606 $aDiseases 606 $aCancer 606 $aHuman physiology 606 $aImmunology 606 $aDiseases 606 $aCancer Biology 606 $aHuman Physiology 615 0$aImmunology. 615 0$aDiseases. 615 0$aCancer. 615 0$aHuman physiology. 615 14$aImmunology. 615 24$aDiseases. 615 24$aCancer Biology. 615 24$aHuman Physiology. 676 $a612.42 702 $aKabashima$b Kenji$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aEgawa$b Gyohei$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910416100203321 996 $aInducible Lymphoid Organs$92546177 997 $aUNINA