LEADER 03544oam 2200649I 450 001 9910411652403321 005 20240424225739.0 010 $a9781000218947 010 $a1000218945 010 $a9780429146060 010 $a042914606X 010 $a9781439824924 010 $a1439824924 010 $a9781439824931 010 $a1439824932 024 7 $a10.1201/b13591 035 $a(CKB)2670000000593707 035 $a(Au-PeEL)EBL4742762 035 $a(CaPaEBR)ebr11317456 035 $a(OCoLC)967107295 035 $a(OCoLC)901280683 035 $a(MiAaPQ)EBC4742762 035 $a(FINmELB)ELB142821 035 $a(ScCtBLL)36cc0ff5-c39b-4072-9ae3-c3cf447d73ff 035 $a(EXLCZ)992670000000593707 100 $a20180706d2010 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 04$aThe cost manual of laboratory animal care and use $erefinement, reduction, and research /$fedited by Bryan Howard, Timo Nevalainen and Gemma Perretta 205 $aFirst edition. 210 1$aBoca Raton, FL :$cCRC Press, an imprint of Taylor and Francis,$d2010. 215 $a1 online resource (424 pages) 311 08$a9781322612515 311 08$a132261251X 311 08$a9781466547810 311 08$a1466547812 320 $aIncludes bibliographical references at the end of each chapters. 327 $achapter 1 Introduction -- chapter 2 Design and Oversight of Laboratory Animal Facilities -- chapter 3 Housing and Care of Laboratory Animals -- chapter 4 Animal Needs and Environmental Refinement -- chapter 5 Ethical Evaluation of ScientificProcedures: Recommendations for Ethics Committees -- chapter 6 Reduction by Careful Design and Statistical Analysis -- chapter 7 Animal Models: Selecting and Preparing Animals for a Study -- chapter 8 Creation of Genetically Modified Animals -- chapter 9 Management of Genetically Modified Rodents -- chapter 10 Impact of Handling,Radiotelemetry, and Food Restriction -- chapter 11 Basic Procedures: Dosing,Sampling and Immunisation -- chapter 12 Imaging Techniques -- chapter 13 Anaesthesia and Analgesia -- chapter 14 Use of Humane Endpointsto Minimise Suffering -- chapter 15 Euthanasia -- chapter 16 Education, Training,and Competence -- chapter 17 Animal Experimentation and Open Communication. 330 3 $aJudge Your Practices Against This Benchmark Manual COST Action B-24 established four working groups to research and discuss issues relevant to laboratory animal science. These included the housing of animals, environmental needs, refinement of procedures, genetically modified animals, and cost-benefit analysis. Based on the groups? findings, The COST Manual of Laboratory Animal Care and Use: Refinement, Reduction, and Research provides a consensual European view of best practices for individuals and institutions caring for and working with laboratory animals. 517 $aCOST Manual of Laboratory Animal Care and Use 606 $aLaboratory animals$vLaboratory manuals 615 0$aLaboratory animals 676 $a636.088/5 676 $a636.0885 702 $aHoward$b Bryan 702 $aNevalainen$b Timo 702 $aPerretta$b Gemma 712 02$aEuropean Cooperation in the Field of Scientific and Technical Research (Organization) 801 0$bFlBoTFG 801 1$bFlBoTFG 906 $aBOOK 912 $a9910411652403321 996 $aThe cost manual of laboratory animal care and use$92116906 997 $aUNINA