LEADER 03958nam 22006255 450 001 9910410051303321 005 20200704121145.0 010 $a3-030-42982-2 024 7 $a10.1007/978-3-030-42982-9 035 $a(CKB)4100000010770692 035 $a(DE-He213)978-3-030-42982-9 035 $a(MiAaPQ)EBC6152170 035 $a(PPN)243226152 035 $a(EXLCZ)994100000010770692 100 $a20200331d2020 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aChemical Epigenetics /$fedited by Antonello Mai 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (IX, 567 p. 80 illus., 50 illus. in color.) 225 1 $aTopics in Medicinal Chemistry,$x1862-2461 ;$v33 311 $a3-030-42981-4 327 $aTargeting the Zinc-Dependent Histone Deacetylases (HDACs) for Drug Discovery -- Hydroxamic Acid-Containing Peptides in the Study of Histone Deacetylases -- Sirtuin Inhibitors and Activators -- Histone Acetyltransferase Enzymes: From Biological Implications to Most Relevant Inhibitors -- Lysine Methyltransferases and Their Inhibitors -- PRMT Inhibitors -- Lysine-Specific Histone Demethylases 1/2 (LSD1/2) and Their Inhibitors -- Inhibitors of JmjC-Containing Histone Demethylases -- Chemical Compounds Targeting DNA Methylation and Hydroxymethylation -- Applied Biophysics for Bromodomain Drug Discovery -- Methyl-Readers and Inhibitors -- Altered Long Non-coding RNA Expression in Cancer: Potential Biomarkers and Therapeutic Targets? - Acetylation and Methylation in Asthma, COPD, and Lung Cancer -- Structure-Based Design ofEpigenetic Inhibitors -- Experimental Methodologies for Detection and Mapping of Epigenetic DNA Marks -- Advanced Assays in Epigenetics. 330 $aThis book presents an authoritative review of the most significant findings about all the epigenetic targets (writers, readers, and erasers) and their implication in physiology and pathology. The book also covers the design, synthesis and biological validation of epigenetic chemical modulators, which can be useful as novel chemotherapeutic agents. Particular attention is given to the chemical mechanisms of action of these molecules and to the drug discovery prose which allows their identification. This book will appeal to students who want to know the extensive progresses made by epigenetics (targets and modulators) in the last years from the beginning, and to specialized scientists who need an instrument to quickly search and check historical and/or updated notices about epigenetics. . 410 0$aTopics in Medicinal Chemistry,$x1862-2461 ;$v33 606 $aPharmaceutical chemistry 606 $aGenetics 606 $aEnzymology 606 $aChemical engineering 606 $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000 606 $aGenetics and Genomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L32000 606 $aEnzymology$3https://scigraph.springernature.com/ontologies/product-market-codes/L14070 606 $aIndustrial Chemistry/Chemical Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/C27000 615 0$aPharmaceutical chemistry. 615 0$aGenetics. 615 0$aEnzymology. 615 0$aChemical engineering. 615 14$aMedicinal Chemistry. 615 24$aGenetics and Genomics. 615 24$aEnzymology. 615 24$aIndustrial Chemistry/Chemical Engineering. 676 $a572.86 676 $a572.865 702 $aMai$b Antonello$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910410051303321 996 $aChemical Epigenetics$92514385 997 $aUNINA