LEADER 04760nam 22006975 450 001 9910409701203321 005 20220408093714.0 010 $a981-15-2517-X 024 7 $a10.1007/978-981-15-2517-9 035 $a(CKB)4100000010858825 035 $a(DE-He213)978-981-15-2517-9 035 $a(MiAaPQ)EBC6157433 035 $a(PPN)243764154 035 $a(EXLCZ)994100000010858825 100 $a20200403d2020 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCoronary Artery Disease: Therapeutics and Drug Discovery /$fedited by Miao Wang 205 $a1st ed. 2020. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2020. 215 $a1 online resource (IX, 339 p. 7 illus., 4 illus. in color.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1177 311 $a981-15-2516-1 327 $aCoronary Artery Disease: From Mechanism to Clinical Practice -- Evidence in guidelines for treatment of coronary artery disease -- Revascularization For Coronary Artery Disease: Principle And Challenges -- Antithrombotic drugs: pharmacology and perspectives -- Lipid modifying drugs: pharmacology and perspectives -- Anti-hypertensive drugs: pharmacology and perspectives -- Pharmaceutical treatment for Heart failure -- Drug discovery for coronary artery disease. 330 $aThis book provides an overview of the etiology of coronary artery disease and focuses on the main therapies and drug interventions currently available. It highlights drug pharmacology and therapeutic challenges, with a special emphasis on the underlying principles of available therapeutics and the on-going development of drugs for coronary artery disease. The book is divided into eight chapters, the first of which describes the classical mechanism of coronary artery disease and its clinical presentations. Chapter 2 lists the principles of and related evidence on the prevention and treatment of coronary artery disease. This includes diet and lifestyle management, and guidelines for the treatment of acute coronary syndrome and stable coronary artery disease. In turn, Chapter 3 describes revascularization treatments, covering percutaneous coronary interventions, coronary artery bypass grafts and thrombolysis. This chapter also addresses the main therapeutic challenges. The following chapters provide an overview of three major categories of coronary artery disease drugs, which target thrombosis (Chapter 4), lipid metabolism (Chapter 5), and hypertension (Chapter 6). Heart failure constitutes the major health burden in the late stage of coronary artery disease; accordingly, current heart failure therapeutics and related drug pharmacology are described in Chapter 7. In closing, Chapter 8 provides a summary of on-going clinical trials for coronary artery disease drug development and discusses a number of promising areas in which intensive research into new therapeutics is being pursued. Given its scope, the book will be of interest to clinicians, medical students and research scientists, as well as to pharmaceutical professionals who are seeking new therapies and drugs for coronary artery disease and related disorders. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1177 606 $aPharmacology 606 $aCardiology 606 $aPharmacotherapy 606 $aCardiac surgery 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aCardiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33037 606 $aPharmacotherapy$3https://scigraph.springernature.com/ontologies/product-market-codes/H69000 606 $aCardiac Surgery$3https://scigraph.springernature.com/ontologies/product-market-codes/H59028 606 $aMalalties coronàries$2thub 606 $aQuimioteràpia$2thub 606 $aCirurgia cardíaca$2thub 608 $aLlibres electrònics$2thub 615 0$aPharmacology. 615 0$aCardiology. 615 0$aPharmacotherapy. 615 0$aCardiac surgery. 615 14$aPharmacology/Toxicology. 615 24$aCardiology. 615 24$aPharmacotherapy. 615 24$aCardiac Surgery. 615 7$aMalalties coronàries 615 7$aQuimioteràpia 615 7$aCirurgia cardíaca 676 $a617.412 702 $aWang$b Miao$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910409701203321 996 $aCoronary Artery Disease: Therapeutics and Drug Discovery$92538481 997 $aUNINA