LEADER 03954nam 22006135 450 001 9910409701103321 005 20250609111515.0 010 $a3-030-41679-8 024 7 $a10.1007/978-3-030-41679-9 035 $a(CKB)4100000010858863 035 $a(DE-He213)978-3-030-41679-9 035 $a(MiAaPQ)EBC6157461 035 $a(PPN)243763697 035 $a(MiAaPQ)EBC6157936 035 $a(EXLCZ)994100000010858863 100 $a20200403d2020 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aXenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense /$fby Chang-Hwei Chen 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (XVII, 239 p. 53 illus., 3 illus. in color.) 311 08$a3-030-41678-X 327 $aOverview -- Foreign Compounds: Foods, Drugs and Other Chemicals -- Absorption, Metabolism and Excretion of Foreign Compounds -- Metabolism of Foreign Compounds -- Bioactivation Metabolism: Activation Enzymes -- Functionalization Reactions Catalyzed by Activation Enzymes -- Detoxifying Metabolism: Detoxification Enzymes -- Conjugation Reactions Catalyzed by Detoxification Enzymes -- Reactive Intermediates Generated from Bioactivation -- Electrophilic Nature of Metabolic Reactive Intermediates -- Oxidative Stress Mediated by Reactive Intermediates -- Xenobiotics Bioactivation - Mediated Cellular Damages -- Nrf2 - ARE Pathway: Defense Against Oxidative Stress -- Genetic Variations and Polymorphisms of Metabolic Enzymes -- Enzyme Polymorphisms Affecting Xenobiotic Toxicity -- Inducibility of foreign Compound Metabolic Enzymes -- Induction of Enzymes for Health Benefits -- Diversity of Metabolic Enzyme Modulators -- Dietary Inducers of Detoxification Enzymes. 330 $aThis book provides a comprehensive, organized, and concise overview of Xenobiotic Metabolic Enzymes and their health implications. The subjects addressed are broad in scope with an emphasis on recent advances in research on biochemical and biomedical aspects of these enzymes. The xenobiotics discussed include not just drugs, but also food, smoke, and other environmental chemicals. The subjects covered in this work include: metabolic enzymes and their catalyzed reactions, reactive intermediates generated from metabolic activation, oxidative stress mediated by electrophilic reactive intermediates, bioactivation - mediated cellular and functional damages, activation of Nrf2 ? ARE pathway, genetic variations affecting metabolic enzyme expression, enzyme polymorphisms affecting xenobiotic - mediated toxicity, induction of metabolic enzymes for health benefits, and a diversity of metabolic enzyme modulators. 606 $aHuman physiology 606 $aEnzymology 606 $aPharmacology 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 606 $aEnzymology$3https://scigraph.springernature.com/ontologies/product-market-codes/L14070 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aXenobiòtics$2thub 606 $aEnzimologia$2thub 608 $aLlibres electrònics$2thub 615 0$aHuman physiology. 615 0$aEnzymology. 615 0$aPharmacology. 615 14$aHuman Physiology. 615 24$aEnzymology. 615 24$aPharmacology/Toxicology. 615 7$aXenobiòtics 615 7$aEnzimologia 676 $a615.9 700 $aChen$b Chang-Hwei$4aut$4http://id.loc.gov/vocabulary/relators/aut$01062885 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910409701103321 996 $aXenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense$92528928 997 $aUNINA