LEADER 05196nam 2200697 450 001 9910814604603321 005 20230807210950.0 010 $a3-11-027896-0 010 $a3-11-038142-7 024 7 $a10.1515/9783110278965 035 $a(CKB)3360000000514920 035 $a(EBL)1094235 035 $a(SSID)ssj0001401390 035 $a(PQKBManifestationID)12594288 035 $a(PQKBTitleCode)TC0001401390 035 $a(PQKBWorkID)11350293 035 $a(PQKB)11311200 035 $a(MiAaPQ)EBC1094235 035 $a(DE-B1597)175331 035 $a(OCoLC)898422381 035 $a(OCoLC)979745314 035 $a(DE-B1597)9783110278965 035 $a(Au-PeEL)EBL1094235 035 $a(CaPaEBR)ebr11006651 035 $a(CaONFJC)MIL807980 035 $a(EXLCZ)993360000000514920 100 $a20140701h20152015 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAnimal cell biotechnology $ein biologics production /$fedited by Hansjo?rg Hauser, Roland Wagner 210 1$aBerlin ;$aBoston :$cWalter de Gruyter GmbH & Company KG,$d[2015] 210 4$d©2015 215 $a1 online resource (718 p.) 300 $aDescription based upon print version of record. 311 $a3-11-027886-3 320 $aIncludes bibliographical references and index. 327 $aUse and perspectives of animal cell culture / Roland Wagner, Hansjo?rg Hauser -- Generation of cell lines and biotechnological applications / Christoph Lipps, Tobias May, Dagmar Wirth -- Cho history, cho evolution and cho genomics : an unsolvable enigma? / Florian Wurm -- Cell lines for vaccine production / Ingo Jordan, Volker Sandig -- Molecular cytogenetics characterization / Roderick A.F. MacLeod, Hans G. Drexler -- Cross-contamination and microbiological contaminations / Wilhelm G. Dirks, Cord C. Uphoff -- Cell line evolution and engineering / Hitto Kaufmann -- Gene amplification and chromosomes / Takeshi Omasa, Kyoungho Lee -- Synthetic mammalian designer cells / David Ausla?nder, Martin Fussenegger -- Rational approaches for transgene expression : targeted integration and episomal maintenance / Natascha Kruse, Shawal Spencer, Dagmar Wirth -- Manipulation of cell growth, metabolism and product quality attributes / Hans Henning von Horsten, Karsten Winkler, Volker Sandig -- Control of biotherapeutics glycosylation / Sandra V. Bennun, Kelley M. Heffner, Emily Blake, Andrew Chung, Michael J. Betenbaugh -- Manufacturing of complex protein products / Lore Florin, Søren K. Rasmussen, Torben P. Frandsen, Anne B. Tolstrup -- Physiology and metabolism of animal cells for production / Venkata Tayi, Michael Butler -- Functional omics for cell lines and processes / Karina Brinkrolf, Raimund Hoffrogge, Matthias Hackl, Andreas Tauch, Martina Baumann, Thomas Noll, Alexander Goesmann, Alfred Pu?hler, Nicole Borth -- Nutrient media for cell culture technology / Claudia Altamirano, Julio Berrios, Mauricio Vergara -- Bioreactors for animal cell culture / Detlef Eisenkraetzer -- High cell density cultivation processes / Natalia Ceaglio, Mariela Bollati-Fogoli?n, Marcos Oggero, Marina Etcheverrigaray, Ricardo B. Kratje -- Industrial cell culture process scale-up strategies and considerations / Weiwei Hu, Kelly Wiltberger -- Extraction and purification of biologics from cell culture / Nuno Fontes, Jens Vogel -- Concepts and technologies for advanced process monitoring and control / John Paul Smelko, Thomas Ryll, Dethardt Mu?ller -- Analytical techniques and quality control of protein therapeutics / Amy Hong Que, Yang Wang, Steven Ziyi Kan -- Process characterization for upstream and downstream development / Vijay Janakiraman, Matt Westoby, Lin Conley -- Spatiotemporally controlled delivery of biopharmaceuticals / Balder Rebmann, Peter van Hoogevest, Matias Zurbriggen, Wilfried Weber. 330 $aThis book introduces fundamental principles and practical application of techniques used in the scalable production of biopharmaceuticals with animal cell cultures. A broad spectrum of subjects relevant to biologics production and manufacturing are reviewed, including the generation of robust cell lines, a survey of functional genomics for a better understanding of cell lines and processes, as well as advances in regulatory compliant upstream and downstream development. The book is an essential reference for all those interested in translational animal cell-based pharmaceutical biotechnology. 606 $aAnimal cell biotechnology 606 $aPharmaceutical biotechnology 610 $aBiologics Manufacturing. 610 $aBiopharmaceutical Engineering. 610 $aBiotechnology. 610 $aCell Culture Engineering. 610 $aVirus Production. 615 0$aAnimal cell biotechnology. 615 0$aPharmaceutical biotechnology. 676 $a660.6 686 $aWX 6603$2rvk 702 $aHauser$b Hansjo?rg$f1949- 702 $aWagner$b Roland$f1956- 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910814604603321 996 $aAnimal cell biotechnology$93964901 997 $aUNINA LEADER 04550nam 22006495 450 001 9910409699303321 005 20251113190132.0 010 $a981-15-0081-9 024 7 $a10.1007/978-981-15-0081-7 035 $a(CKB)4100000011034848 035 $a(DE-He213)978-981-15-0081-7 035 $a(MiAaPQ)EBC6175308 035 $a(PPN)24375972X 035 $a(MiAaPQ)EBC6175382 035 $a(EXLCZ)994100000011034848 100 $a20200413d2020 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAdvances in Synthetic Biology /$fedited by Vijai Singh 205 $a1st ed. 2020. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2020. 215 $a1 online resource (XIII, 349 p. 75 illus., 63 illus. in color.) 311 08$a981-15-0080-0 327 $aChapter 1. Introduction to Synthetic Biology -- Chapter 2. Current progress in synthetic genetic networks -- Chapter 3. Current Progress and Limitations in the Design, Construction and Characterization of Synthetic Parts -- Chapter 4. Recent progress in DNA parts standardization and characterization -- Chapter 5. Current status and challenges of DNA sequencing -- Chapter 6. Biomimetic approaches in synthetic biology -- Chapter 7. Design principles of synthetic biological oscillators -- Chapter 8. SOFTWARE-AIDED DESIGN OF IDEALISED PROGRAMMABLE NUCLEIC ACID CIRCUITS -- Chapter 9. Digital Circuit Design for Biological and Silicon Computers -- Chapter 10. Engineering of riboregulators for gene regulation as a tool for synthetic biology -- Chapter 11. Recent advances, challenges and opportunities in riboswitches -- Chapter 12. Recent Advances in Gene and Genome Assembly: Challenges and Implications -- Chapter 13. Recent advances, challenges and opportunities in synthetic genomes -- Chapter 14. Expansion of the genetic code -- Chapter 15. Expanding the potential of CRISPR-Cas9 technology for crops improvement -- Chapter 16. Synthetic biology at the hand of cell-free systems -- Chapter 17. Synthetic Biology for the Rapid, Precise and Compliant Detection of Microbes -- Chapter 18. Application and challenges of synthetic biology -- Chapter 19. Development and Application of Microfluidics in Synthetic Biology -- Chapter 20. The Ethics of Synthetic Biology Research and Development: A Principlist Approach. . 330 $aThis book addresses the design of emerging conceptual tools, technologies and systems including novel synthetic parts, devices, circuits, oscillators, biological gates, and small regulatory RNAs (riboregulators and riboswitches), which serve as versatile control elements for regulating gene expression. Synthetic biology, a rapidly growing field that involves the application of engineering principles in biology, is now being used to develop novel systems for a wide range of applications including diagnostics, cell reprogramming, therapeutics, enzymes, vaccines, biomaterials, biofuels, fine chemicals and many more. The book subsequently summarizes recent developments in technologies for assembling synthetic genomes, minimal genomes, synthetic biology toolboxes, CRISPR-Cas systems, cell-free protein synthesis systems and microfluidics. Accordingly, it offers a valuable resource not only for beginners in synthetic biology, but also for researchers, students, scientists,clinicians, stakeholders and policymakers interested in the potential held by synthetic biology. 606 $aBioinformatics 606 $aBiotechnology 606 $aMolecular genetics 606 $aMedical genetics 606 $aElectronic circuits 606 $aComputational and Systems Biology 606 $aChemical Bioengineering 606 $aMolecular Genetics 606 $aMedical Genetics 606 $aElectronic Circuits and Systems 615 0$aBioinformatics. 615 0$aBiotechnology. 615 0$aMolecular genetics. 615 0$aMedical genetics. 615 0$aElectronic circuits. 615 14$aComputational and Systems Biology. 615 24$aChemical Bioengineering. 615 24$aMolecular Genetics. 615 24$aMedical Genetics. 615 24$aElectronic Circuits and Systems. 676 $a660.6 702 $aSingh$b Vijai$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910409699303321 996 $aAdvances in Synthetic Biology$92495851 997 $aUNINA