LEADER 00988nas# 22002651i 450 001 UON00503756 005 20231205105426.469 011 $a0870-6824 100 $a20200915b19421974 |0itac50 ba 101 $apor 102 $aPT 105 $a|||| 1|||| 110 $aaX||||||||| 200 1 $aBrasilia$fUniversidade de Coimbra 210 $a1942-1974 215 $aCoimbra$cFaculdade de Letras da Universidade de Coimbra, 1942-1974. 620 $aPT$dCoimbra$3UONL002407 712 02$aUniversidade de Coimbra$3UONV115716 712 $aUniversidade de Coimbra. Faculdade de Letras$3UONV272928$4650 801 $aIT$bSOL$c20240220$gRICA 899 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$2UONSI$41942-1961;$cPER DUOMO 151 ; 912 $aUON00503756 950 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$bSI 1942-1961;$dSI PER DUOMO 151 1942 $eSI PRV49749 7 1942 996 $aBrasilia$9506641 997 $aUNIOR LEADER 05570nam 22007815 450 001 9910409698803321 005 20250609110821.0 010 $a3-030-40204-5 024 7 $a10.1007/978-3-030-40204-4 035 $a(CKB)4100000011040240 035 $a(DE-He213)978-3-030-40204-4 035 $a(MiAaPQ)EBC6177148 035 $a(PPN)243764170 035 $a(MiAaPQ)EBC6177224 035 $a(EXLCZ)994100000011040240 100 $a20200415d2020 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHSF1 and Molecular Chaperones in Biology and Cancer /$fedited by Marc Laurence Mendillo, David Pincus, Ruth Scherz-Shouval 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (VIII, 182 p. 31 illus., 26 illus. in color.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1243 311 08$a3-030-40203-7 327 $aPreface: Dedication to Susan Lindquist -- Part I: Structure -- Structural and Biochemical properties of Hsp40/Hsp70 chaperone system -- The TRiC/CCT chaperonin and its role in uncontrolled proliferation -- Regulation of Hsf1 and the heat shock response -- Part II: Function -- Challenging proteostasis: Role of the chaperone network to control aggregation-prone proteins in human disease -- The multifaceted role of HSF1 in tumorigenesis -- Chaperome networks ? redundancy and implications for cancer treatment -- Chaperones in the tumor microenvironment -- The impact of the ER unfolded protein response on cancer initiation and progression: Therapeutic implications -- Part III: Therapies -- The right tool for the job: an overview of Hsp90 inhibitors -- Lessons learned from proteasome inhibitors, the paradigm for targeting protein homeostasis in cancer -- Reflections and outlook on targeting HSP90, HSP70 and HSF1 in cancer: A personal perspective. 330 $aProtein homeostasis, or ?Proteostasis?, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter ?Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective? is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1243 606 $aHuman genetics 606 $aCancer$xResearch 606 $aMolecular biology 606 $aProteomics 606 $aProteins 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aProteomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L1403X 606 $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040 606 $aProtein Structure$3https://scigraph.springernature.com/ontologies/product-market-codes/L14050 606 $aProteïnes$2thub 606 $aOncologia$2thub 608 $aLlibres electrònics$2thub 615 0$aHuman genetics. 615 0$aCancer$xResearch. 615 0$aMolecular biology. 615 0$aProteomics. 615 0$aProteins. 615 14$aHuman Genetics. 615 24$aCancer Research. 615 24$aMolecular Medicine. 615 24$aProteomics. 615 24$aProtein Science. 615 24$aProtein Structure. 615 7$aProteïnes. 615 7$aOncologia 676 $a572.633 702 $aMendillo$b Marc Laurence$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aPincus$b David$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aScherz-Shouval$b Ruth$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910409698803321 996 $aHSF1 and Molecular Chaperones in Biology and Cancer$92510077 997 $aUNINA