LEADER 05178nam 22006975 450 001 9910409698203321 005 20220401100753.0 010 $a3-030-35805-4 024 7 $a10.1007/978-3-030-35805-1 035 $a(CKB)4100000011126746 035 $a(DE-He213)978-3-030-35805-1 035 $a(MiAaPQ)EBC6177517 035 $a(PPN)243764081 035 $a(EXLCZ)994100000011126746 100 $a20200417d2020 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCirculating Tumor Cells in Breast Cancer Metastatic Disease /$fedited by Roberto Piņeiro 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (XV, 167 p. 15 illus., 14 illus. in color.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1220 311 $a3-030-35804-6 327 $aPreface -- Introduction ? Biology of Breast Cancer Metastasis and Importance of the Analysis of CTCs -- Epithelial-Mesenchymal Plasticity in Circulating Tumor Cells, the Precursors of Metastasis -- Disseminated Tumor Cells and Dormancy in Breast Cancer Progression -- Methodology for the Isolation and Analysis of CTCs -- Advances in the Characterization of Circulating Tumor Cells in Metastatic Breast Cancer: Single Cell Analyses and Interactions, and Patient-derived Models for Drug Testing -- Circulating Tumor Cells (CTCs) Heterogeneity in Metastatic Breast Cancer: Different Approaches for Different Needs -- Relevance of CTC Clusters in Breast Cancer Metastasis -- Epigenetics of Circulating Tumor Cells in Breast Cancer -- Circulating Tumor Cells: Applications for Early Breast Cancer -- Clinical Relevance and Therapeutic Application of CTCs in Advanced Breast Cancer. . 330 $aThis book compiles the latest research and key findings about the role of circulating tumor cells (CTCs) in Breast Cancer progression, both from the research and clinical standpoint. Based on latest advancements, the content of the book is set out to provide a clear overview about the biology and use of CTCs as a tool for the monitoring and management of breast cancer patients. This work covers basic concepts about the process of metastasis, the biology of CTCs and their potential applications as a biomarker in breast cancer. It will enable readers to delve into the process of epithelial-mesenchymal plasticity (EMP), mechanisms and clinical implications of tumor cell dormancy and minimal residual disease, and into the phenotypical and molecular heterogeneity of CTCs and CTC clusters, including the epigenetic characterization of CTCs. Readers will find out about the key technologies used for the isolation of CTCs as well as the latest advances towards the characterization of CTCs, involving single cell analyses and patient-derived models. It will discuss the evidences about the use of CTCs as a tool to monitor breast cancer progression and therapy response, as well as to unravel mechanisms of resistance to therapy and to identify new therapeutic targets favoring the development of novel anticancer drugs. Lastly, it will discuss ongoing clinical trials and try to foresee the future of CTCs in terms of clinical application and implementation in the clinical routine. The topic of this book is particularly relevant for cancer researchers and oncologist with an interest in the field, looking to refresh or to broaden their knowledge and understanding about the use of CTCs as a diagnostic biomarker in breast cancer. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1220 606 $aCancer research 606 $aMolecular biology 606 $aBiomedical engineering 606 $aStem cells 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aBiomedical Engineering/Biotechnology$3https://scigraph.springernature.com/ontologies/product-market-codes/B24000 606 $aStem Cells$3https://scigraph.springernature.com/ontologies/product-market-codes/L16010 606 $aCāncer de mama$2thub 606 $aCčl·lules canceroses$2thub 606 $aMonitoratge de pacients$2thub 608 $aLlibres electrōnics$2thub 615 0$aCancer research. 615 0$aMolecular biology. 615 0$aBiomedical engineering. 615 0$aStem cells. 615 14$aCancer Research. 615 24$aMolecular Medicine. 615 24$aBiomedical Engineering/Biotechnology. 615 24$aStem Cells. 615 7$aCāncer de mama 615 7$aCčl·lules canceroses 615 7$aMonitoratge de pacients 676 $a616.99449042 702 $aPiņeiro$b Roberto$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910409698203321 996 $aCirculating Tumor Cells in Breast Cancer Metastatic Disease$92523067 997 $aUNINA