LEADER 03903nam 22006735 450 001 9910409697703321 005 20220309122608.0 010 $a981-15-2389-4 024 7 $a10.1007/978-981-15-2389-2 035 $a(CKB)4100000011208546 035 $a(MiAaPQ)EBC6178565 035 $a(DE-He213)978-981-15-2389-2 035 $a(PPN)243764138 035 $a(EXLCZ)994100000011208546 100 $a20200417d2020 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAnimal Models of Human Birth Defects$b[electronic resource] /$fedited by Aimin Liu 205 $a1st ed. 2020. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2020. 215 $a1 online resource (vii, 244 pages) $cillustrations 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1236 311 $a981-15-2388-6 327 $aChapter 1: Using forward and reverse genetics in mouse to study birth defects -- Chapter 2: Using animals to study neural tube defects -- Chapter 3: Using animals to study ciliopathies -- Chapter 4: Using animals to model human skeletal defects -- Chapter 5: Understanding eye defects using animal models -- Chapter 6: Modelling kidney and urinary tract defects in animals -- Chapter 7: Pancreas development and type I diabetes -- Chapter 8: Using animals to study human birth defects affecting the functions of the digestive system -- Chapter 9: Modelling human birth defects with zebrafish -- Chapter 10: Modelling diseases with C. elegans -- Chapter 11: Infectious disease and birth defects. 330 $aThis book focuses on the use of animal models to study various human defects. It summarizes our current understanding of a variety of common human birth defects and the essential role of animal models in shedding light on the underlying mechanisms of these disorders. Birth defects are the leading cause of infant deaths, and cost billions of dollars in care for those affected. Unfortunately, the lack of a clear understanding of the mechanisms leading to many of these developmental disorders has hindered effective prevention and early intervention strategies. Studies using animal models have provided essential insights into several human birth defects. This book serves as a valuable reference resource for researchers and graduate students who are interested in learning the basic principles as well as the latest advances in the study of the mechanisms of human birth defects. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1236 606 $aLaboratory medicine 606 $aAnimal models in research 606 $aMolecular biology 606 $aLaboratory Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B15007 606 $aAnimal Models$3https://scigraph.springernature.com/ontologies/product-market-codes/L25050 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aMalformacions$2thub 606 $aNaixement$2thub 606 $aInvestigació$2thub 606 $aExperimentació animal$2thub 608 $aLlibres electrònics$2thub 615 0$aLaboratory medicine. 615 0$aAnimal models in research. 615 0$aMolecular biology. 615 14$aLaboratory Medicine. 615 24$aAnimal Models. 615 24$aMolecular Medicine. 615 7$aMalformacions 615 7$aNaixement 615 7$aInvestigació 615 7$aExperimentació animal 676 $a616.043 702 $aLiu$b Aimin$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910409697703321 996 $aAnimal Models of Human Birth Defects$92528926 997 $aUNINA