LEADER 05205nam 22007335 450 001 9910409695203321 005 20220520132731.0 010 $a3-030-41283-0 024 7 $a10.1007/978-3-030-41283-8 035 $a(CKB)4100000011231724 035 $a(DE-He213)978-3-030-41283-8 035 $a(MiAaPQ)EBC6192280 035 $a(PPN)248394967 035 $a(EXLCZ)994100000011231724 100 $a20200507d2020 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMechanisms of Genome Protection and Repair$b[electronic resource] /$fedited by Dmitry O. Zharkov 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (XVI, 220 p. 30 illus., 20 illus. in color.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1241 300 $aIncludes index. 311 $a3-030-41282-2 327 $aPreface -- Kinetic Milestones of Damage Recognition by DNA Glycosylases of the Helix?Hairpin?Helix Structural Superfamily -- Protein Engineering of DNA-Dependent Enzymes -- A Multifunctional Protein PolDIP2 in DNA Translesion Synthesis -- Impact of PARP1, PARP2 and PARP3 on the Base Excision Repair of Nucleosomal DNA -- Base Excision Repair in Chromatin and the Requirement for Chromatin Remodelling -- DNA Repair and Mutagenesis in Vertebrate Mitochondria: Evidence for Asymmetric DNA Strand Inheritance -- Mystery of Expansion: DNA Metabolism and Unstable Repeats -- The Detection of 8-Oxo-7,8-Dihydro-2?-Deoxyguanosine in Circulating Cell-Free DNA: A Step Towards Longitudinal Monitoring of Health -- Biotransformation and Toxicities of Aristolochic Acids -- Mechanisms of Sugar Beet Response to Biotic and Abiotic Stresses -- Studying ALS: Current Approaches, Effect on Potential Treatment Strategy. 330 $aThis volume is about DNA damage and repair. It covers recent advances in several important research areas of this rapidly expanding field, and does so at several levels, from individual molecules to organisms. The topics include mechanisms of damage recognition by DNA repair enzymes, chromatin response to DNA damage, special ways of mutagenesis, biomarkers of genotoxicity, and the integrated organism response to genotoxic and other kinds of stress. The book starts with two chapters about structural and mechanistic features of protein?DNA interactions that ensure fast and reliable discrimination between targets ? be it DNA modifications or specific sequences ? and non-targets. Examples of particular proteins and their function in repair regulation, translesion synthesis and chromatin remodeling are discussed in the following three chapters. Next, more attention is given to the mutagenic consequences of failed or aberrant DNA repair, particularly in mitochondria and in runs of trinucleotide repeats. Moving to a human health-oriented view, the book presents data on two kinds of lesions, the widely found 8-oxoguanine and the dietary genotoxic adducts with aristolochic acids, as biomarkers of general oxidative stress and specific exposure, respectively. Two final chapters are devoted to the interplay of multiple factors, including genotoxic stress, in the complex phenotypes in humans (amyotrophic lateral sclerosis ) and plants (abiotic stress response). This volume will be of significant interest for scientists working in the field of DNA repair as well as for the general biochemistry and molecular biology audience. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1241 606 $aHuman genetics 606 $aCell biology 606 $aBiochemistry 606 $aMolecular biology 606 $aCancer research 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aReparació de l'ADN$2thub 606 $aGenčtica humana$2thub 608 $aLlibres electrňnics$2thub 615 0$aHuman genetics. 615 0$aCell biology. 615 0$aBiochemistry. 615 0$aMolecular biology. 615 0$aCancer research. 615 14$aHuman Genetics. 615 24$aCell Biology. 615 24$aBiochemistry, general. 615 24$aMolecular Medicine. 615 24$aCancer Research. 615 7$aReparació de l'ADN 615 7$aGenčtica humana 676 $a575.1 702 $aZharkov$b Dmitry O$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910409695203321 996 $aMechanisms of Genome Protection and Repair$92495849 997 $aUNINA