LEADER 04345nam 22007695 450 001 9910409694703321 005 20240208115709.0 010 $a3-030-40406-4 024 7 $a10.1007/978-3-030-40406-2 035 $a(CKB)4100000011232502 035 $a(DE-He213)978-3-030-40406-2 035 $a(MiAaPQ)EBC6195933 035 $a(PPN)248394959 035 $a(EXLCZ)994100000011232502 100 $a20200512d2020 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMolecular and Cellular Biology of Phagocytosis /$fedited by Maurice B. Hallett 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (X, 189 p. 66 illus., 58 illus. in color.) 225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1246 311 $a3-030-40405-6 327 $aAn introduction to phagocytosis -- A Brief History of Phagocytosis -- The role of membrane surface charge in phagocytosis -- Receptor models of phagocytosis: the effect of target shape -- Decision Making in Phagocytosis -- Membrane tension and the role of ezrin during phagocytosis -- Molecular mechanisms of calcium signaling during phagocytosis -- Calpain activation by Ca2+ and its role in phagocytosis -- The NADPH oxidase and the phagosome -- Conclusions and the future of phagocytosis.-. 330 $aPhagocytosis is the engulfment of particulate matter by cells. It is a fundamental (and probably ?primitive?) cell biological process which is important in single celled organisms such as amoeba; multicellular animals including coelenterates; and in higher animals. In humans and other mammals, specialised immune cells (phagocytes) utilise phagocytosis in their crucial role of engulfing and destroying infecting microbes. Yet, surprisingly, the biophysics and biochemistry underlying the process has only become clear recently with the advent of genetic manipulation and advances in single cell imaging. In this volume, the aim is to bring together recent fundamental advances that give a clear picture of the underlying mechanism involved in phagocytosis. Not only is this an important topic in its own right, but a full understanding of the process will have a potential impact on human medicine, since as antibiotics become less effective in fight infection, researchers are looking at alternative approaches, including enhancing the ?natural? immunity brought about by immune phagocytes. The aim is to provide a comprehensive volume on the topic, with separate chapters on identified recent advances, each written by the major contributors in each area. In addition, the volume will attempt to give a wider overview than is often the case in single author reviews, with an emphasis here on the cell biological understanding of phagocytosis using biophysical approaches alongside the biochemical and imaging approaches. 410 0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1246 606 $aImmunology 606 $aMedicine?Research 606 $aBiology?Research 606 $aMedical microbiology 606 $aCytology 606 $aBiochemistry 606 $aImmunology 606 $aBiomedical Research 606 $aMedical Microbiology 606 $aCell Biology 606 $aBiochemistry 606 $aFagocitosi$2thub 606 $aCitologia$2thub 606 $aBiologia molecular$2thub 608 $aLlibres electrònics$2thub 615 0$aImmunology. 615 0$aMedicine?Research. 615 0$aBiology?Research. 615 0$aMedical microbiology. 615 0$aCytology. 615 0$aBiochemistry. 615 14$aImmunology. 615 24$aBiomedical Research. 615 24$aMedical Microbiology. 615 24$aCell Biology. 615 24$aBiochemistry. 615 7$aFagocitosi 615 7$aCitologia 615 7$aBiologia molecular 676 $a616.079 702 $aHallett$b Maurice B$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910409694703321 996 $aMolecular and Cellular Biology of Phagocytosis$92509536 997 $aUNINA