LEADER 04349nam 22006495 450 001 9910409693303321 005 20220603100048.0 010 $a3-030-42246-1 024 7 $a10.1007/978-3-030-42246-2 035 $a(CKB)4100000011254574 035 $a(MiAaPQ)EBC6202766 035 $a(DE-He213)978-3-030-42246-2 035 $a(PPN)248397427 035 $a(EXLCZ)994100000011254574 100 $a20200518d2020 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMolecular Genetics of Axial Patterning, Growth and Disease in Drosophila Eye$b[electronic resource] /$fedited by Amit Singh, Madhuri Kango-Singh 205 $a2nd ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (xiv, 368 pages) $cillustrations 300 $aIncludes index. 311 $a3-030-42245-3 327 $aEarly eye development: Specification and Determination -- Generation of third dimension: Axial patterning in the developing Drosophila eye -- Catching the Next Wave: Patterning of the Drosophila eye by the Morphogenetic Furrow -- Ghost in the Machine- the Peripodail Epithelium -- Cell Polarity in Drosophila Retina -- Negative regulation for neural patterning in the Drosophila eye -- Adhesion and the cytoskeleton in the Drosophila pupaleye -- Drosophila eye as a model to study regulation of growth control: The discovery of size control pathways -- Drosophila cancer modeling using the eye imaginal discs -- Recent contributions of the Drosophila eye to unraveling the basis of neurodegeneration -- Genetic regulation of early eye development in non-dipteran insects -- Eyes for an eye: A comparative account on compound eye of Drosophila melanogaster with vertebrate eye -- Index. 330 $aDrosophila melanogaster (fruit fly) is a highly versatile model with a genetic legacy of more than a century. It provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology is how a multi-cellular organism develops from a single-celled embryo. The discovery of the genes responsible for pattern formation has helped refine this question and has led to other questions, such as the role of various genetic and cell biological pathways in regulating the process of pattern formation and growth during organogenesis. The Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This updated second edition covers current progress in the study of molecular genetic mechanisms of pattern formation, mutations in axial patterning, genetic regulation of growth, and more using the Drosophila eye as a model. 606 $aHuman genetics 606 $aAnimal models in research 606 $aAnimal genetics 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aAnimal Models$3https://scigraph.springernature.com/ontologies/product-market-codes/L25050 606 $aAnimal Genetics and Genomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L32030 606 $aDrosòfila$2thub 606 $aOftalmopaties$2thub 606 $aOrganogènesi$2thub 608 $aLlibres electrònics$2thub 615 0$aHuman genetics. 615 0$aAnimal models in research. 615 0$aAnimal genetics. 615 14$aHuman Genetics. 615 24$aAnimal Models. 615 24$aAnimal Genetics and Genomics. 615 7$aDrosòfila 615 7$aOftalmopaties 615 7$aOrganogènesi 676 $a573.21 702 $aSingh$b Amit$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aKango-Singh$b Madhuri$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910409693303321 996 $aMolecular Genetics of Axial Patterning, Growth and Disease in Drosophila Eye$92532339 997 $aUNINA