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010   $a3-030-44599-2
024 7 $a10.1007/978-3-030-44599-7
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035   $a(MiAaPQ)EBC6207846
035   $a(DE-He213)978-3-030-44599-7
035   $a(PPN)248394843
035   $a(EXLCZ)994100000011263817
100   $a20200521d2020      u|             0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aNrf2 and its Modulation in Inflammation$b[electronic resource] /$fedited by Huai Deng
205   $a1st ed. 2020.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020.
215   $a1 online resource (210 pages)
225 1 $aProgress in Inflammation Research,$x0379-0363 ;$v85
311   $a3-030-44597-6 
320   $aIncludes bibliographical references.
327   $aChapter 1. Molecular mechanisms of Nrf2 in inflammation: Interactions between Nrf2 and inflammatory mediators -- Chapter 2. Nrf2 in immune responses during inflammation -- Chapter 3. Nrf2 and Nrf2-interacting network in respiratory inflammation and diseases -- Chapter 4. Nrf2 in the regulation of endothelial cell homeostasis during inflammation -- Chapter 5. The roles of Nrf2 in cardiovascular system and atherosclerosis -- Chapter 6. Nrf2 and inflammation-triggered carcinogenesis -- Chapter 7. Role of Nrf2 in oxidative and inflammatory processes in obesity and metabolic diseases -- Chapter 8. Modulators of Nrf2 Activation during Inflammation.
330   $aNrf2, a transcription factor that mediates transcriptional responses to oxidative and xenobiotic stresses, plays a central role in cellular protection against internal or external toxins. Defects in Nrf2 and the relevant regulatory pathways are associated with a number of pathologies including inflammation,respiratory diseases, cardiovascular dysfunctions, metabolic syndrome and diabetes, neurodegeneration, and cancer. This book comprehensively reviews the up-to-date discoveries for the roles of Nrf2 in several human diseases in the context of inflammation. In particular, the molecular mechanisms that mediate the functions of Nrf2 and its interacting network in inflammation and pathogenesis are explicated. In addition, the research and therapeutic applications of Nrf2-targeting compounds in different diseases were summarized. This book is expected to be a valuable reference for worldwide researchers conducting both mechanistic and therapeutic studies of Nrf2 and relevant factors.
410  0$aProgress in Inflammation Research,$x0379-0363 ;$v85
606   $aImmunology
606   $aCell physiology
606   $aGene expression
606   $aOxidative stress
606   $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000
606   $aCell Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L33010
606   $aGene Expression$3https://scigraph.springernature.com/ontologies/product-market-codes/B12010
606   $aOxidative Stress$3https://scigraph.springernature.com/ontologies/product-market-codes/L16070
606   $aExpressió gènica$2thub
606   $aProteïnes$2thub
606   $aImmunitat cel·lular$2thub
608   $aLlibres electrònics$2thub
615  0$aImmunology.
615  0$aCell physiology.
615  0$aGene expression.
615  0$aOxidative stress.
615 14$aImmunology.
615 24$aCell Physiology.
615 24$aGene Expression.
615 24$aOxidative Stress.
615  7$aExpressió gènica
615  7$aProteïnes
615  7$aImmunitat cel·lular
676   $a572.8845
702   $aDeng$b Huai$4edt$4http://id.loc.gov/vocabulary/relators/edt
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910409692703321
996   $aNrf2 and its Modulation in Inflammation$92543884
997   $aUNINA