LEADER 01145nas 2200397 a 450 001 996213185003316 005 20221130121303.0 035 $a(OCoLC)39319723 035 $a(CKB)1000000000528784 035 $a(CONSER)sn 98039299 035 $a(DE-599)ZDB2064532-6 035 $a(NjHacI)991000000000528784 035 $a(EXLCZ)991000000000528784 100 $a19980604a19929999 sy 101 0 $aeng 135 $aurcnu||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAddiction treatment forum 210 $a[Mundelein, Ill.?] $cLandmark Group$d1992- 210 1$aMundelein, Ill :$cLandmark Group,$d1992. 215 $a1 online resource 606 $aSubstance abuse$xTreatment$vPeriodicals 606 $aSubstance-Related Disorders$xtherapy 608 $aPeriodicals. 615 0$aSubstance abuse$xTreatment 615 12$aSubstance-Related Disorders$xtherapy. 676 $a362.29 712 02$aLandmark Group, 801 0$bNjHacI 801 1$bNjHacl 906 $aJOURNAL 912 $a996213185003316 996 $aAddiction treatment forum$92296226 997 $aUNISA LEADER 03884nam 22006735 450 001 9910409691303321 005 20251116224322.0 010 $a3-030-38062-9 024 7 $a10.1007/978-3-030-38062-5 035 $a(CKB)4100000011273701 035 $a(MiAaPQ)EBC6209002 035 $a(DE-He213)978-3-030-38062-5 035 $a(PPN)248394932 035 $a(EXLCZ)994100000011273701 100 $a20200525d2020 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMyosins $eA Superfamily of Molecular Motors /$fedited by Lynne M. Coluccio 205 $a2nd ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (xi, 455 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1239 311 08$a3-030-38061-0 327 $aIntroduction -- Myosin Structure -- Cargo Binding by Unconventional Myosins -- Cryo-EM of Actin-Myosin Structures -- Small Molecule Effectors of Myosin Function -- Single-Molecule Biophysical Techniques to Study Actomyosin Force Transduction -- High-Speed Atomic Force Microscopy to Study Myosin Motility -- How Myosin 5 Walks Deduced from Single-Molecule Biophysical Approaches -- How Actin Tracks Affect Myosin Motors -- Myosins in the Nucleus -- Myosins in Cytokinesis -- Myosins and Disease -- Myosins and Hearing -- The Actomyosin Systems in Apicomplexa -- Approaches to Identify and Characterise MYO6-Cargo Interactions -- Class IX Myosins: Motorized RhoGAP Signaling Molecules -- Myosin X -- Myosin XVI -- Myosin XVIII -- Myosin XIX. 330 $aMyosins are molecular motors that use the energy from ATP hydrolysis to move and exert tension on actin filaments. Although the best-known myosin is myosin II, which powers skeletal muscle contraction, there are at least two dozen classes of myosins, and cells generally express multiple isoforms. Myosins are involved in multiple cellular activities including cell structure, cell migration, intracellular trafficking, and cell-cell contact. Importantly, loss of function and mutation are associated with diseases including myopathies, hearing impairment, glomerulosclerosis, and cancer. Written by international experts in myosin motors and the approaches used to study them, this book is expected to provide a comprehensive assessment of the current status of our understanding of the structure and molecular mechanism of myosins and their cellular roles. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1239 606 $aMolecular biology 606 $aProteins 606 $aCytology 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aProtein Structure$3https://scigraph.springernature.com/ontologies/product-market-codes/L14050 606 $aProteïnes$2thub 606 $aEstructura molecular$2thub 606 $aCitologia$2thub 608 $aLlibres electrònics$2thub 615 0$aMolecular biology. 615 0$aProteins. 615 0$aCytology. 615 14$aMolecular Medicine. 615 24$aProtein Science. 615 24$aCell Biology. 615 24$aProtein Structure. 615 7$aProteïnes 615 7$aEstructura molecular 615 7$aCitologia 676 $a572.6 702 $aColuccio$b Lynne M.$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910409691303321 996 $aMyosins$92139476 997 $aUNINA