LEADER 04752nam 22007695 450 001 9910409685703321 005 20230629202610.0 010 $a981-15-4798-X 024 7 $a10.1007/978-981-15-4798-0 035 $a(CKB)5280000000218594 035 $a(MiAaPQ)EBC6219814 035 $a(DE-He213)978-981-15-4798-0 035 $a(PPN)248594109 035 $a(EXLCZ)995280000000218594 100 $a20200602d2020 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aIschemiRs: MicroRNAs in Ischemic Stroke$b[electronic resource] $eFrom Basics to Clinics /$fby Rajanikant G. K., Pierre Gressens, Sreekala S. Nampoothiri, Gokul Surendran, Cindy Bokobza 205 $a1st ed. 2020. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2020. 215 $a1 online resource (146 pages) 311 $a981-15-4797-1 327 $aPreface -- Chapter 1: microRNAs in normal brain physiology -- Chapter 2: Ischemic stroke: An imperative need for effective therapy -- Chapter 3: MicroRNAs in ischemic stroke pathophysiology: Special emphasis on early molecular events -- Chapter 4: microRNA regulation of ischemic stroke inflammatory and immune response -- Chapter 5: Regulatory role of microRNAs in ischemic cell death -- Chapter 6: The emerging role of microRNAs in post-ischemic angiogenesis and neurogenesis -- Chapter 7: MicroRNAs as potential diagnostic, prognostic and therapeutic biomarkers in ischemic stroke -- Chapter 8: Interplay between microRNAs and other cerebrovascular diseases -- Chapter 9: New insights into the regulatory role of lncRNA, circRNA, piRNAs, and ceRNAs in ischemic stroke -- Chapter 10: Computational resources for microRNA research -- Chapter 11: MicroRNA-targeted therapeutics for ischemic stroke: Status, gaps and the way forward. 330 $aThere has been an enormous increase in information relating to microRNA (miRNA) and its strategic role in numerous diseases. This book reviews the emerging role of microRNAs in cerebral ischemia, providing comprehensive details of the links between this small RNA molecule and ischemic stroke, the more prevalent of the two main types of stroke. The chapters address questions relating to microRNA?s function in various pathological features of stroke, like oxidative stress, excitotoxicity and cell death, as well as its role as a biomarker and diagnostic agent, and the current therapeutic interventions. Further, the book highlights the latest research on how miRNAs contribute to neuroregeneration following stroke, discussing the myriad computational tools and databases used in miRNA research, and decsribes how how miRNA modulates other cerebrovascular diseases. The book concludes with fresh insights into the effect of long non-coding RNA in cerebral ischemia. 606 $aNeurosciences 606 $aHuman genetics 606 $aImmunology 606 $aApoptosis 606 $aOxidative stress 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aApoptosis$3https://scigraph.springernature.com/ontologies/product-market-codes/L16060 606 $aOxidative Stress$3https://scigraph.springernature.com/ontologies/product-market-codes/L16070 606 $aMalalties cerebrovasculars$2thub 606 $aRNA$2thub 606 $aExpressió gènica$2thub 608 $aLlibres electrònics$2thub 615 0$aNeurosciences. 615 0$aHuman genetics. 615 0$aImmunology. 615 0$aApoptosis. 615 0$aOxidative stress. 615 14$aNeurosciences. 615 24$aHuman Genetics. 615 24$aImmunology. 615 24$aApoptosis. 615 24$aOxidative Stress. 615 7$aMalalties cerebrovasculars 615 7$aRNA 615 7$aExpressió gènica 676 $a616.81 700 $aG. K$b Rajanikant$4aut$4http://id.loc.gov/vocabulary/relators/aut$0949968 702 $aGressens$b Pierre$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aNampoothiri$b Sreekala S$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aSurendran$b Gokul$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aBokobza$b Cindy$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910409685703321 996 $aIschemiRs: MicroRNAs in Ischemic Stroke$92147636 997 $aUNINA