LEADER 04691nam 22007095 450 001 9910409684703321 005 20200701004633.0 010 $a981-15-2902-7 024 7 $a10.1007/978-981-15-2902-3 035 $a(CKB)5300000000003501 035 $a(DE-He213)978-981-15-2902-3 035 $a(MiAaPQ)EBC6129309 035 $a(PPN)243224656 035 $a(EXLCZ)995300000000003501 100 $a20200305d2020 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aKetamine $eFrom Abused Drug to Rapid-Acting Antidepressant /$fedited by Kenji Hashimoto, Soichiro Ide, Kazutaka Ikeda 205 $a1st ed. 2020. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2020. 215 $a1 online resource (V, 189 p. 27 illus., 13 illus. in color.) 311 $a981-15-2901-9 327 $a1.Determination of ketamine in the river of China -- 2.Ketamine abuse in Taiwan -- 3.Ketamine problem in Hong Kong -- 4. Hair analysis of ketamine -- 5. Brain imaging of ketamine abusers -- 6.Management of complications of ketamine abuse -- 7.Action site of ketamine in the NMDA receptor channel -- 8.Synaptic modulation in the effect of ketamine -- 9.Rodents whole-brain imaging in the effects of ketamine -- 10. Behavioral pharmacology of ketamine: An overview of preclinical studies -- 11.Antidepressant potential of ketamine enantiomers -- 12.Effects of ketamine on pain-related depression -- 13.Role of gut microbiota in the antidepressant actions of ketamine and its enantiomers -- 14. The role of NMDA receptor GluN2D subunit in the effects of ketamine and enantiomers -- 15.Roles of the lateral habenula in the actions of ketamine -- 16.Comparison of antidepressant action of ketamine and group II mGlu receptor antagonists -- 17.Antidepressant effects of ketamine in Taiwanese patients with treatment-resistant depression. 330 $aThis book presents the latest data from basic research and clinical trials supporting the effectiveness of ketamine as a treatment for depression, bipolar disorder, and suicidal behavior, setting these positive findings within the context of the serious problem of ketamine abuse. The first part of the book focuses on the evidence regarding ketamine abuse, with specific reference to Asian countries, and discusses countermeasures and complication management. It then addresses the mechanisms underlying the antidepressant and side effects of ketamine, which have remained elusive, describing and discussing important new research findings. Further, it explains insights gained from whole brain imaging in rodents and from behavioral pharmacology, and presents evidence regarding the role of gut microbiota, the NMDA receptor GluN2D subunit, and the lateral habenula in the actions of ketamine. These advances form the basis for the safer use of ketamine in patients with treatment-resistant depression and are expected to lead to the development of new antidepressants. . 606 $aNeurosciences 606 $aPharmacology 606 $aDiagnosis, Laboratory 606 $aNeurobiology 606 $aNeuropsychology 606 $aNeurology 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aLaboratory Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B15007 606 $aNeurobiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L25066 606 $aNeuropsychology$3https://scigraph.springernature.com/ontologies/product-market-codes/Y12030 606 $aNeurology$3https://scigraph.springernature.com/ontologies/product-market-codes/H36001 615 0$aNeurosciences. 615 0$aPharmacology. 615 0$aDiagnosis, Laboratory. 615 0$aNeurobiology. 615 0$aNeuropsychology. 615 0$aNeurology. 615 14$aNeurosciences. 615 24$aPharmacology/Toxicology. 615 24$aLaboratory Medicine. 615 24$aNeurobiology. 615 24$aNeuropsychology. 615 24$aNeurology. 676 $a615.781 702 $aHashimoto$b Kenji$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aIde$b Soichiro$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aIkeda$b Kazutaka$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910409684703321 996 $aKetamine$92034066 997 $aUNINA