LEADER 03820nam 22005175 450 001 9910409682803321 005 20220615102738.0 010 $a3-030-45493-2 024 7 $a10.1007/978-3-030-45493-7 035 $a(CKB)5310000000016732 035 $a(MiAaPQ)EBC6236226 035 $a(DE-He213)978-3-030-45493-7 035 $a(PPN)248596187 035 $a(EXLCZ)995310000000016732 100 $a20200623d2020 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aNeurodevelopmental Disorders $eEmploying iPSC Technologies to Define and Treat Childhood Brain Diseases /$fedited by Emanuel DiCicco-Bloom, James H. Millonig 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (307 pages) 225 1 $aAdvances in Neurobiology,$x2190-5215 ;$v25 311 $a3-030-45492-4 327 $a1. Modeling neurodevelopmental deficits in Tuberous Sclerosis Complex with stem cell-derived neural precursors and neurons -- 2. Advances in human stem cells and genome editing to understand and develop treatment for Fragile X syndrome -- 3. IPSC MODELS OF CHROMOSOME 15Q IMPRINTING DISORDERS: FROM DISEASE MODELING TO THERAPEUTIC STRATEGIES -- 4. Creating iPSC based models to understand the signaling and cellular phenotypes in idiopathic autism and 16p11.2 derived neurons -- 5. Dysregulation of Neurite Outgrowth and Cell Migration in Autism and other Neurodevelopmental Disorders -- 6. Investigation of Schizophrenia with Human Induced Pluripotent Stem Cells -- 7. Modeling Inflammation on Neurodevelopmental disorders using pluripotent stem cells -- 8. Astrocyte-derived exosomes in an iPSC model of bipolar disorder -- 9. Two- and there-dimensional stem cell models to define mechanisms underlying psychiatric disorders -- 10. Development of a 3-D organoid system using human induced pluripotent stem cells to model idiopathic autism. 330 $aThis book contains a compendium of induced pluripotent stem cells (iPSCs) articles and reviews concerning state of the art technologies and how they are being applied to human neurodevelopmental disorders. With the establishment of effective technologies to produce iPSCs and their derivatives, like neural precursors, neurons, and glia, researchers have new platforms to study neurodevelopmental disorders. iPSC technology enables researchers to study how human neurons develop in individuals with neurodevelopmental disorders, providing an unparalleled opportunity to investigate their etiology. In turn, researchers have now begun to understand the underlying molecular and cellular pathways that contribute to human diseases. iPSCs technologies also provide an emerging tool for future translational studies and disease classification. The chapters will emphasize how among the diverse idiopathic and genetic disorders, there are common clinical as well as cellular and molecular phenotypes. 410 0$aAdvances in Neurobiology,$x2190-5215 ;$v25 606 $aNeurosciences 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aMalalties neurodegeneratives$2thub 608 $aLlibres electrònics$2thub 615 0$aNeurosciences. 615 14$aNeurosciences. 615 7$aMalalties neurodegeneratives 676 $a618.9 702 $aDiCicco-Bloom$b Emanuel$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMillonig$b James H$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910409682803321 996 $aNeurodevelopmental disorders$92056464 997 $aUNINA