LEADER 05332nam 22009615 450 001 9910404118403321 005 20230629203322.0 010 $a3-030-38281-8 024 7 $a10.1007/978-3-030-38281-0 035 $a(CKB)4100000011223431 035 $a(MiAaPQ)EBC6190678 035 $a(DE-He213)978-3-030-38281-0 035 $a(Au-PeEL)EBL6190678 035 $a(OCoLC)1153071610 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/31839 035 $a(PPN)24376331X 035 $a(EXLCZ)994100000011223431 100 $a20200430d2020 fy 0 101 0 $aeng 135 $aurnn#---mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aPan-genome diversity, dynamics and evolution of genomes /$feditors, Hervé Tettelin, Duccio Medini 205 $a1st edition 2020. 210 $aCham$cSpringer Nature$d2020 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (XIV, 307 p. 47 illus., 43 illus. in color.) 311 $a3-030-38280-X 327 $aPart 1: Genomic diversity and the pan-genome concept -- Chapter 1: The pan-genome: a data-drivendiscovery in biology -- Chapter 2: The prokaryotic species concept and challenges -- Chapter 3: Bacterial guide on how to design a diversified gene portfolio -- Chapter 4: A review of pan-genome tools and recent studies -- Part 2: Evolutionary biology of pan-genomes -- Chapter 5: Structure and dynamics of bacterial populations: pan-genome ecology -- Chapter 6: Bacterial microevolution and the pan-genome -- Chapter 7: Pan-genomes and selection: the public goods hypothesis -- Chapter 8: A pan-genomic perspective on the emergence, maintenance and predictability of antibiotic resistance -- Part 3: Pan-genomics: an open, evolving discipline -- Chapter 9: Metapangenome: at the crossroad of pangenomics and metagenomics -- Chapter 10: Pan-genome flux balance analysis towards pan-phenomes -- Chapter 11: Bacterial epigenomics: epigenetics in the age of population genomics -- Chapter 12: Eukaryotic pan-genomes -- Chapter 13: Computational strategies for eukaryotic pan-genome analyses. 330 $aThis open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book?s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics. 606 $aGenomes 606 $aGenomics 606 $aGenomes$2thub 606 $aBiologia molecular$2thub 608 $aLlibres electrònics$2thub 610 $aMicrobial Genetics and Genomics 610 $aEvolutionary Biology 610 $aGenetics and Population Dynamics 610 $aMicrobial Ecology 610 $aHuman Genetics 610 $aGenetics and Genomics 610 $aComparative genomics 610 $aMetagenomics 610 $aMicrobial Population Analysis 610 $aPangenome Profile 610 $aSupra-Genome Analysis 610 $aAdaptive Evolution 610 $aComputational Tools 610 $aBioinformatic Genomics 610 $aCore Dispensable Genome 610 $aSelection, Recombination, Composition 610 $aAcquired Resistance 610 $aBacterial Species Concept 610 $aGenomic Diversity 610 $aBacterial Ecology, Microevolution 610 $aOpen Access 610 $aPan-metagenomics 610 $aPan-microbiomics 610 $aPan-epigenome 610 $aGene Transfer 610 $aPan-phenomes 610 $aMicrobiology (non-medical) 610 $aGenetics (non-medical) 610 $aEvolution 610 $aApplied mathematics 610 $aEcological science, the Biosphere 610 $aMedical genetics 615 0$aGenomes. 615 0$aGenomics. 615 7$aGenomes 615 7$aBiologia molecular 676 $a579.135 700 $aTettelin$b Hervé$4edt$01355999 702 $aTettelin$b Hervé$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMedini$b Duccio$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910404118403321 996 $aPan-genome diversity, dynamics and evolution of genomes$93360223 997 $aUNINA