LEADER 05065nam 2201333z- 450 001 9910404092003321 005 20231214132837.0 010 $a3-03928-587-4 035 $a(CKB)4100000011302218 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/40131 035 $a(EXLCZ)994100000011302218 100 $a20202102d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAdipokines 2.0 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 electronic resource (406 p.) 311 $a3-03928-586-6 330 $aOnce viewed solely as fat storage cells, adipocytes and their adipokines have now been proven to be central for human health. Understanding that overweight and obesity may increase the risk for various diseases requires detailed characterization of adipokine function. Weight gain, weight regain, and fasting affect adipocyte health and accordingly their secretome. Different adipose tissue deposits exist and they vary in cellular composition and function. The evidence is strong of a role of adipokines in cancer, reproductive function, neurological diseases, cardiovascular diseases ,and rheumatoid arthritis. Adipokines are considered useful biomarkers for adipose tissue and metabolic health, and may be used as diagnostic tools in rheumatoid arthritis, cancer, or sepsis. This book contains 10 original articles and 9 review articles focusing on these bioactive peptides. Several articles deal with chemerin, an adipokine discovered more than 20 years ago. Data so far have resulted in promising insights related to its biological function. We are only beginning to understand the multiple roles of chemerin, the mechanisms regulating its activity, and the signaling pathways used by this chemokine. Adipokine receptor agonists and antagonists may result in the formulation of novel drugs and ultimately may lead to new therapeutic targets to be used in clinical practice. 610 $alipids 610 $acathepsins 610 $aneurodegeneration 610 $atocilizumab 610 $aSGBS adipocytes 610 $achemerin receptors 610 $acholesterol 610 $ametabolically healthy obese 610 $aenergy metabolism 610 $aadipose-brain axis 610 $aEP3 receptor 610 $aleptin 610 $arheumatoid arthritis 610 $aexcessive gestational weight gain 610 $ain vitro fat regain 610 $asecreted frizzled-related protein 5 610 $aPCOS 610 $aEP4 receptor 610 $aleukocyte 610 $aexchange protein directly activated by cAMP isoform 2 (EPAC2) 610 $aextracellular remodeling 610 $ainsulin 610 $aosteoarthritis 610 $alipid metabolism 610 $afat mass 610 $aTango bioassay 610 $afatty liver 610 $afree fatty acids 610 $alabel-free proteomic profiling 610 $ainterleukin(IL)-33 610 $asick fat 610 $apolycystic ovary syndrome 610 $aearly-life programming 610 $ainflammation 610 $agestational diabetes 610 $aglucose restriction 610 $aadipokines 610 $aneonatal anthropometry 610 $aepicardial adipose tissue (EAT) 610 $aoestrous cycle 610 $aCardiovascular Diseases (CVDs) 610 $atriglycerides 610 $aG protein-coupled receptor 1 610 $atesticular pathologies 610 $aprognosis 610 $aovary 610 $aICU 610 $abiologic activity 610 $apreeclempsia 610 $aadipokine 610 $acritical illness 610 $aearly pregnancy 610 $amyokine 610 $aliver steatosis 610 $aC-C chemokine receptor-like 2 610 $atestis 610 $astimulating growth factor 2 (ST2) 610 $apig 610 $afitness 610 $ahuman granulosa cells 610 $aobesity 610 $aproteolysis 610 $aannexins 610 $aadipose tissue 610 $abiomarker 610 $aghrelin 610 $abrain health 610 $asepsis 610 $aadiponectin 610 $arheumatic diseases 610 $achemokine-like receptor 1 610 $afollicular fluid 610 $aglucose homeostasis 610 $aresistin 610 $aNonalcoholic fatty liver disease 610 $aprostaglandin E2 (PGE2) 610 $avisceral fat 610 $amicroglia 610 $aweight regain 610 $acomplement factors 610 $aalpha-fetoprotein 610 $apolycystic ovary morphology 610 $achemerin 610 $acancer 610 $adepression 610 $ahypertension 610 $ahypothalamus 700 $aBu?chler$b Christa$4auth$01323732 906 $aBOOK 912 $a9910404092003321 996 $aAdipokines 2.0$93035787 997 $aUNINA