LEADER 05160nam 2201381z- 450 001 9910404092003321 005 20210211 010 $a3-03928-587-4 035 $a(CKB)4100000011302218 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/40131 035 $a(oapen)doab40131 035 $a(EXLCZ)994100000011302218 100 $a20202102d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAdipokines 2.0 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (406 p.) 311 08$a3-03928-586-6 330 $aOnce viewed solely as fat storage cells, adipocytes and their adipokines have now been proven to be central for human health. Understanding that overweight and obesity may increase the risk for various diseases requires detailed characterization of adipokine function. Weight gain, weight regain, and fasting affect adipocyte health and accordingly their secretome. Different adipose tissue deposits exist and they vary in cellular composition and function. The evidence is strong of a role of adipokines in cancer, reproductive function, neurological diseases, cardiovascular diseases ,and rheumatoid arthritis. Adipokines are considered useful biomarkers for adipose tissue and metabolic health, and may be used as diagnostic tools in rheumatoid arthritis, cancer, or sepsis. This book contains 10 original articles and 9 review articles focusing on these bioactive peptides. Several articles deal with chemerin, an adipokine discovered more than 20 years ago. Data so far have resulted in promising insights related to its biological function. We are only beginning to understand the multiple roles of chemerin, the mechanisms regulating its activity, and the signaling pathways used by this chemokine. Adipokine receptor agonists and antagonists may result in the formulation of novel drugs and ultimately may lead to new therapeutic targets to be used in clinical practice. 606 $aMedicine$2bicssc 610 $aadipokine 610 $aadipokines 610 $aadiponectin 610 $aadipose tissue 610 $aadipose-brain axis 610 $aalpha-fetoprotein 610 $aannexins 610 $abiologic activity 610 $abiomarker 610 $abrain health 610 $aC-C chemokine receptor-like 2 610 $acancer 610 $aCardiovascular Diseases (CVDs) 610 $acathepsins 610 $achemerin 610 $achemerin receptors 610 $achemokine-like receptor 1 610 $acholesterol 610 $acomplement factors 610 $acritical illness 610 $adepression 610 $aearly pregnancy 610 $aearly-life programming 610 $aenergy metabolism 610 $aEP3 receptor 610 $aEP4 receptor 610 $aepicardial adipose tissue (EAT) 610 $aexcessive gestational weight gain 610 $aexchange protein directly activated by cAMP isoform 2 (EPAC2) 610 $aextracellular remodeling 610 $afat mass 610 $afatty liver 610 $afitness 610 $afollicular fluid 610 $afree fatty acids 610 $aG protein-coupled receptor 1 610 $agestational diabetes 610 $aghrelin 610 $aglucose homeostasis 610 $aglucose restriction 610 $ahuman granulosa cells 610 $ahypertension 610 $ahypothalamus 610 $aICU 610 $ain vitro fat regain 610 $ainflammation 610 $ainsulin 610 $ainterleukin(IL)-33 610 $alabel-free proteomic profiling 610 $aleptin 610 $aleukocyte 610 $alipid metabolism 610 $alipids 610 $aliver steatosis 610 $ametabolically healthy obese 610 $amicroglia 610 $amyokine 610 $an/a 610 $aneonatal anthropometry 610 $aneurodegeneration 610 $aNonalcoholic fatty liver disease 610 $aobesity 610 $aoestrous cycle 610 $aosteoarthritis 610 $aovary 610 $aPCOS 610 $apig 610 $apolycystic ovary morphology 610 $apolycystic ovary syndrome 610 $apreeclempsia 610 $aprognosis 610 $aprostaglandin E2 (PGE2) 610 $aproteolysis 610 $aresistin 610 $arheumatic diseases 610 $arheumatoid arthritis 610 $asecreted frizzled-related protein 5 610 $asepsis 610 $aSGBS adipocytes 610 $asick fat 610 $astimulating growth factor 2 (ST2) 610 $aTango bioassay 610 $atesticular pathologies 610 $atestis 610 $atocilizumab 610 $atriglycerides 610 $avisceral fat 610 $aweight regain 615 7$aMedicine 700 $aBu?chler$b Christa$4auth$01323732 906 $aBOOK 912 $a9910404092003321 996 $aAdipokines 2.0$93035787 997 $aUNINA