LEADER 05266nam 2201537z- 450 001 9910404091403321 005 20231214132836.0 010 $a3-03928-699-4 035 $a(CKB)4100000011302224 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/43261 035 $a(EXLCZ)994100000011302224 100 $a20202102d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCirculating Tumor Cells: Finding Rare Events for A Huge Knowledge of Cancer Dissemination 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 electronic resource (366 p.) 311 $a3-03928-698-6 330 $aThe analysis of circulating tumor cells (CTCs) as a real-time liquid biopsy approach can be used to obtain new insights into metastasis biology, and as companion diagnostics to improve the stratification of therapies and to obtain insights into the therapy-induced selection of cancer cells. In this book, we will cover all the different facets of CTCs to assemble a huge corpus of knowledge on cancer dissemination: technologies for their enrichment, detection, and characterization; their analysis at the single-cell level; their journey as CTC microemboli; their clinical relevance; their biology with the epithelial-to-mesenchymal transition (EMT); their stem-cell properties; their potential to initiate metastasis at distant sites; their ex vivo expansion; and their escape from the immune system. 517 $aCirculating Tumor Cells 610 $aFOLFIRINOX 610 $aimmunofluorescence imaging 610 $aAR-V7 610 $acirculating tumour cells 610 $achemoradioresistance 610 $aCTC-based treatment decisions 610 $arVAR2 610 $aimmunophenotyping 610 $aimmune system 610 $aCellSearch® 610 $aflow cytometry 610 $aclinical trials 610 $acirculating tumor DNA 610 $asynaptophysin 610 $astem cells 610 $acolorectal cancer 610 $amelanoma 610 $aCTC biology 610 $aplatelets 610 $aAR 610 $aCTC capture technology 610 $acastration resistant prostate cancer (CRPC) 610 $aPD-L1 expression 610 $arovalpituzumab tesirine 610 $aHMB-45 610 $athymidylate synthase 610 $actDNA 610 $atumor cell dissemination 610 $asolid cancers 610 $ametastasis 610 $alocally advanced rectal cancer 610 $amiRNA 610 $aepithelial-to-mesenchymal transition (EMT) 610 $aNSCLC 610 $atumor biomarkers 610 $atumor stem cells 610 $acirculating tumor cells 610 $amajor histocompatibility complex class I (MHCI) 610 $abone marrow 610 $aheterogeneity 610 $acerebrospinal liquid biopsy 610 $afish 610 $aglioma 610 $ain vivo flow cytometry 610 $acolorectal surgery 610 $aCellSearch 610 $asingle-cell analysis 610 $adisseminated tumor cells 610 $aEasyCount slides 610 $amicrosatellite instability 610 $acirculating plasma cells 610 $acirculating leukemia cells 610 $aARV7 610 $aSLUG 610 $aandrogen receptor 610 $ametastatic colorectal cancer 610 $aleukocyte-derived extracellular vesicles 610 $aprostate cancer (PCa) 610 $aneutrophils 610 $aliquid biopsy 610 $aenzalutamide 610 $aCD133 610 $aenrichment and detection technologies 610 $abiomarkers 610 $aimmune checkpoint inhibitors 610 $abiomarker 610 $aRAD23B 610 $amicrobiome 610 $aintegrin B1 610 $aACCEPT 610 $aemboli 610 $asmall-cell lung carcinoma 610 $aEPISPOT 610 $amicrofluidics 610 $aearly breast cancer 610 $acirculating tumor cells (CTC) 610 $atumor-initiating cells (TICs) 610 $aimmunomodulation 610 $axenograft models 610 $aCTC-derived xenografts 610 $amalaria 610 $acirculating tumor cells (CTCs) 610 $aclinical utility 610 $aexosomes 610 $aliquid surgery 610 $actRNA 610 $aCTCs 610 $aepithelial-mesenchymal transition 610 $atargeted therapy 610 $ahematological cells 610 $agene expression analysis 610 $ahepatocellular carcinoma (HCC) 610 $abreast cancer 610 $aEpCAM enrichment 610 $aprostate cancer 610 $aCTC 610 $aabiraterone 610 $afibronectin 610 $aCTC-derived ex vivo models 610 $aCTMat 610 $achromogranin A 610 $aCTM 610 $aexosome 700 $aAlix-Panabieres$b Catherine$4auth$01296959 906 $aBOOK 912 $a9910404091403321 996 $aCirculating Tumor Cells: Finding Rare Events for A Huge Knowledge of Cancer Dissemination$93024332 997 $aUNINA