LEADER 04554nam 2201237z- 450 001 9910404087603321 005 20210212 010 $a3-03928-783-4 035 $a(CKB)4100000011302262 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/58616 035 $a(oapen)doab58616 035 $a(EXLCZ)994100000011302262 100 $a20202102d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aRoles and Functions of ROS and RNS in Cellular Physiology and Pathology 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (230 p.) 311 08$a3-03928-782-6 330 $aOur common knowledge on oxidative stress has evolved substantially over the years and has been mostly focused on the fundamental chemical reactions and the most relevant chemical species involved in the human pathophysiology of oxidative stress-associated diseases. Thus, reactive oxygen species and reactive nitrogen species (ROS and RNS) were identified as the key players initiating, mediating, and regulating the cellular and biochemical complexity of oxidative stress either as physiological (acting pro-hormetic) or as pathogenic (causing destructive vicious circle) process. The papers published in this particular Special Issue of the Cells demonstrate the impressive pathophysiological relevance of ROS and RNS in a range of contexts, including the relevance of second messengers of free radicals like 4-hydroxynonenal, allowing us to assume that even more detailed mechanisms of their positive and negative effects lie in wait, and should assist in better monitoring of the major modern diseases and the development of advanced integrative biomedicine treatments. 606 $aMedicine and Nursing$2bicssc 610 $a4-hydroxynonenal 610 $a4-hydroxynonenal (4-HNE) 610 $aacrolein 610 $aantimicrobial 610 $aantioxidant 610 $aantioxidants 610 $aaorta 610 $abEnd.3 610 $abEnd5 610 $ablood-brain barrier 610 $aCa2+ 610 $acalcium 610 $acancer 610 $acancer cells 610 $acancer regression 610 $acannabidiol 610 $acell signaling 610 $acyclopurines 610 $aDNA and RNA polymerases 610 $aDNA damage 610 $aendothelial cells 610 $afree radicals 610 $afusion/fission 610 $aglucose deprivation 610 $aglutamine deprivation 610 $aglutathione 610 $agranulocytes 610 $agrowth 610 $agrowth control 610 $aheme-oxygenase-1 610 $ahistamine 610 $ahuman neuroblastoma SH-SY5Y cells 610 $ahydroxyapatite-based biomaterials 610 $aIMR-90 610 $ainflammation 610 $aintermittent hypoxia 610 $aintracellular signaling 610 $akeratinocytes 610 $aLC-MS/MS 610 $alipid peroxidation 610 $amacrophages 610 $aMFN2 610 $amitochondria 610 $aNADPH-oxidase 610 $aneuronal cell death 610 $aNF?B 610 $aNQO1 transcript variants 610 $aNrf2 610 $aNRF2-NQO1 axis 610 $anuclear factor erythroid 2-related factor 2 610 $anucleotide excision repair 610 $aoptical coherence tomography 610 $aosteoblast growth 610 $aoxidative burst 610 $aoxidative homeostasis 610 $aoxidative metabolism of the cells 610 $aoxidative stress 610 $apathophysiology of oxidative stress 610 $aplaque vulnerability 610 $aproliferation 610 $areactive oxygen species 610 $areactive oxygen species (ROS) 610 $aredox balance 610 $arelaxation 610 $aROS 610 $ars1800566 610 $atoll-like receptors 610 $atoxicity 610 $aTP53 mutation 610 $aTRPM2 channel 610 $aUV radiation 610 $aVAS2870 610 $aviability 610 $avitamins 610 $avon Willebrand factor 610 $axeroderma pigmentosum 615 7$aMedicine and Nursing 700 $aZarkovic$b Neven$4auth$01287827 906 $aBOOK 912 $a9910404087603321 996 $aRoles and Functions of ROS and RNS in Cellular Physiology and Pathology$93020454 997 $aUNINA