LEADER 03611nam 2200697 450 001 9910829064603321 005 20190411214423.0 010 $a90-04-30430-4 024 7 $a10.1163/9789004304307 035 $a(CKB)3710000000652303 035 $a(EBL)4526177 035 $a(SSID)ssj0001667978 035 $a(PQKBManifestationID)16457779 035 $a(PQKBTitleCode)TC0001667978 035 $a(PQKBWorkID)15001928 035 $a(PQKB)11489133 035 $a(PQKBManifestationID)16457816 035 $a(PQKB)21357350 035 $a(MiAaPQ)EBC4526177 035 $a(OCoLC)946142577 035 $a(nllekb)BRILL9789004304307 035 $a(EXLCZ)993710000000652303 100 $a20160406d2016 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAntoni van Leeuwenhoek $emaster of the minuscule /$fby Lesley Robertson, Jantien Backer ... [and others] 210 1$aLeiden ;$aBoston :$cBrill,$d[2016] 215 $a1 online resource (246 p.) 300 $a"This English translation has been made by Peter Mason and Lesley Robertson. 300 $a"This book was originally published in Dutch, entitled Van Leeuwenhoek: Groots in het kleine, by Veen Media, Amsterdam (2014)" -- Title page verso. 311 $a90-04-30428-2 320 $aIncludes bibliographical references and index. 327 $aPreliminary Material -- 1 The Early Years -- 2 Return to Delft -- 3 Antoni?s First Brush with Science -- 4 Van Leeuwenhoek?s Microscopes -- 5 Antoni van Leeuwenhoek and His Microorganisms -- 6 The Discovery of the ?Semine genitali Animalculis? or Spermatozoa -- 7 Antoni van Leeuwenhoek and the Question of Generation -- 8 The Circulation of Blood -- 9 Secrets of Nature -- 10 The Famous Van Leeuwenhoek -- 11 The End of a Long Life -- 12 The Scientific Legacy of Antoni van Leeuwenhoek -- Timeline -- Afterword -- Selected Bibliography -- Index. 330 $aIn Antoni van Leeuwenhoek, Master of the Minuscule , the Father of Microbiology is presented in the context of his time, relationships and the Dutch Golden Age. Although he lacked an academic education, he dedicated his life to investigating the microscopic world using handmade, single-lensed microscopes and magnifiers. An expert observer, he planned experiments and designed equipment to test his theories. His pioneering discoveries included blood cells, protozoa, bacteria and spermatozoa, and resulted in an international reputation among the scientific and upper classes of 17th and 18th century Europe, aided by his Fellowship of the Royal Society of London. This lavishly illustrated biography sets his legacy of scientific achievements against the ideas and reactions of his fellow scientists and other contemporaries. 606 $aMicrobiologists$zNetherlands$vBiography 606 $aMicroscopy$xHistory 606 $aBiologists$zNetherlands$vBiography 606 $aBiologists$2fast 606 $aMicrobiologists$2fast 606 $aMicroscopy$2fast 607 $aNetherlands$2fast 608 $aBiography.$2fast 608 $aHistory.$2fast 615 0$aMicrobiologists 615 0$aMicroscopy$xHistory. 615 0$aBiologists 615 7$aBiologists. 615 7$aMicrobiologists. 615 7$aMicroscopy. 676 $a579.092 700 $aBacker$b Jantien$01717279 701 $aRobertson$b Lesley$g(Lesley Anna)$01717280 801 0$bNL-LeKB 801 1$bNL-LeKB 906 $aBOOK 912 $a9910829064603321 996 $aAntoni van Leeuwenhoek$94113337 997 $aUNINA LEADER 03299nam 2200877z- 450 001 9910404084303321 005 20210211 010 $a3-03928-255-7 035 $a(CKB)4100000011302295 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/50093 035 $a(oapen)doab50093 035 $a(EXLCZ)994100000011302295 100 $a20202102d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aIn-Cell NMR Spectroscopy: Biomolecular Structure and Function 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (152 p.) 311 08$a3-03928-254-9 330 $aThis Special Issue examines state-of-the-art in-cell NMR spectroscopy as it relates to biological systems of increasing complexity. The compendia of research and recent innovations from prominent laboratories in the field of solid state and solution in-cell NMR spectroscopy, metabolomics and technology development are presented. The work establishes in-cell NMR spectroscopy as the premier method for determining the structures and interaction capabilities of biological molecules at high resolution within the delicately intricate interior of living cells, and the means of utilizing cells as living laboratories to directly assess the effects of exogenous and endogenous stimuli on cell physiology.] 517 $aIn-Cell NMR Spectroscopy 606 $aBiology, life sciences$2bicssc 610 $a2D INADEQUATE 610 $aAdenylate kinase 610 $aantimicrobial peptide 610 $across-correlated relaxation 610 $acrystalline and amorphous starch 610 $aDihydrofolate reductase 610 $aDNA 610 $aDNP 610 $adrug discovery 610 $aenzyme activity 610 $aenzyme kinetics 610 $ain-cell NMR 610 $ain-situ NMR 610 $aintrinsically disordered proteins 610 $alipid membrane 610 $alive cell 610 $amagic-angle spinning 610 $amammalian cells 610 $aMARK2 phosphorylation 610 $amRNA 610 $aNMR spectroscopy 610 $anon-uniform sampling 2 610 $aparamagnetic effects 610 $apost-translational modifications 610 $aprotein dynamics 610 $aprotein interactions 610 $aprotein modification 610 $aprotein NMR 610 $aprotein structure 610 $aprotein structure determination 1 610 $aprotein structure-function 610 $areview 610 $aRibosome 610 $arRNA 610 $asolid-state NMR 610 $aspectrum reconstruction 3 610 $astructural calculation 4 610 $astructure function 610 $atarget engagement 610 $aTau 610 $aThioredoxin 610 $aThymidylate synthase 610 $atime-resolved NMR 610 $awhole cell NMR 615 7$aBiology, life sciences 700 $aBurz$b David S$4auth$01278676 702 $aShekhtman$b Alexander$4auth 906 $aBOOK 912 $a9910404084303321 996 $aIn-Cell NMR Spectroscopy: Biomolecular Structure and Function$93013715 997 $aUNINA