LEADER 03299nam 2200877z- 450 001 9910404084303321 005 20210211 010 $a3-03928-255-7 035 $a(CKB)4100000011302295 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/50093 035 $a(oapen)doab50093 035 $a(EXLCZ)994100000011302295 100 $a20202102d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aIn-Cell NMR Spectroscopy: Biomolecular Structure and Function 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (152 p.) 311 08$a3-03928-254-9 330 $aThis Special Issue examines state-of-the-art in-cell NMR spectroscopy as it relates to biological systems of increasing complexity. The compendia of research and recent innovations from prominent laboratories in the field of solid state and solution in-cell NMR spectroscopy, metabolomics and technology development are presented. The work establishes in-cell NMR spectroscopy as the premier method for determining the structures and interaction capabilities of biological molecules at high resolution within the delicately intricate interior of living cells, and the means of utilizing cells as living laboratories to directly assess the effects of exogenous and endogenous stimuli on cell physiology.] 517 $aIn-Cell NMR Spectroscopy 606 $aBiology, life sciences$2bicssc 610 $a2D INADEQUATE 610 $aAdenylate kinase 610 $aantimicrobial peptide 610 $across-correlated relaxation 610 $acrystalline and amorphous starch 610 $aDihydrofolate reductase 610 $aDNA 610 $aDNP 610 $adrug discovery 610 $aenzyme activity 610 $aenzyme kinetics 610 $ain-cell NMR 610 $ain-situ NMR 610 $aintrinsically disordered proteins 610 $alipid membrane 610 $alive cell 610 $amagic-angle spinning 610 $amammalian cells 610 $aMARK2 phosphorylation 610 $amRNA 610 $aNMR spectroscopy 610 $anon-uniform sampling 2 610 $aparamagnetic effects 610 $apost-translational modifications 610 $aprotein dynamics 610 $aprotein interactions 610 $aprotein modification 610 $aprotein NMR 610 $aprotein structure 610 $aprotein structure determination 1 610 $aprotein structure-function 610 $areview 610 $aRibosome 610 $arRNA 610 $asolid-state NMR 610 $aspectrum reconstruction 3 610 $astructural calculation 4 610 $astructure function 610 $atarget engagement 610 $aTau 610 $aThioredoxin 610 $aThymidylate synthase 610 $atime-resolved NMR 610 $awhole cell NMR 615 7$aBiology, life sciences 700 $aBurz$b David S$4auth$01278676 702 $aShekhtman$b Alexander$4auth 906 $aBOOK 912 $a9910404084303321 996 $aIn-Cell NMR Spectroscopy: Biomolecular Structure and Function$93013715 997 $aUNINA