LEADER 03196nam 2200841z- 450 001 9910404084303321 005 20231214133245.0 010 $a3-03928-255-7 035 $a(CKB)4100000011302295 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/50093 035 $a(EXLCZ)994100000011302295 100 $a20202102d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aIn-Cell NMR Spectroscopy: Biomolecular Structure and Function 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 electronic resource (152 p.) 311 $a3-03928-254-9 330 $aThis Special Issue examines state-of-the-art in-cell NMR spectroscopy as it relates to biological systems of increasing complexity. The compendia of research and recent innovations from prominent laboratories in the field of solid state and solution in-cell NMR spectroscopy, metabolomics and technology development are presented. The work establishes in-cell NMR spectroscopy as the premier method for determining the structures and interaction capabilities of biological molecules at high resolution within the delicately intricate interior of living cells, and the means of utilizing cells as living laboratories to directly assess the effects of exogenous and endogenous stimuli on cell physiology.] 517 $aIn-Cell NMR Spectroscopy 610 $aprotein NMR 610 $atime-resolved NMR 610 $aRibosome 610 $astructural calculation 4 610 $acrystalline and amorphous starch 610 $ain-cell NMR 610 $aprotein dynamics 610 $aDNP 610 $aprotein modification 610 $aTau 610 $aspectrum reconstruction 3 610 $amRNA 610 $aThioredoxin 610 $aprotein structure 610 $aprotein interactions 610 $adrug discovery 610 $aprotein structure determination 1 610 $areview 610 $aenzyme activity 610 $aMARK2 phosphorylation 610 $apost-translational modifications 610 $aDihydrofolate reductase 610 $amammalian cells 610 $atarget engagement 610 $anon-uniform sampling 2 610 $aparamagnetic effects 610 $aprotein structure-function 610 $across-correlated relaxation 610 $astructure function 610 $arRNA 610 $a2D INADEQUATE 610 $alipid membrane 610 $aThymidylate synthase 610 $awhole cell NMR 610 $aenzyme kinetics 610 $amagic-angle spinning 610 $alive cell 610 $asolid-state NMR 610 $aAdenylate kinase 610 $aDNA 610 $ain-situ NMR 610 $aantimicrobial peptide 610 $aNMR spectroscopy 610 $aintrinsically disordered proteins 700 $aBurz$b David S$4auth$01278676 702 $aShekhtman$b Alexander$4auth 906 $aBOOK 912 $a9910404084303321 996 $aIn-Cell NMR Spectroscopy: Biomolecular Structure and Function$93013715 997 $aUNINA