LEADER 03763nam 2200913z- 450 001 9910404084003321 005 20210211 010 $a3-03928-481-9 035 $a(CKB)4100000011302298 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/48390 035 $a(oapen)doab48390 035 $a(EXLCZ)994100000011302298 100 $a20202102d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aGenetic and Epigenetic Modulation of Cell Functions by Physical Exercise 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (170 p.) 311 08$a3-03928-480-0 330 $aFrom an evolutionary perspective, our species has relied upon physical activity for most of its history to survive and has had to escape from predators, to scavenge for food, and to use physique to work or build necessary means for everyday life. Physical activity has been part of our evolution and progress since the very beginning and, consequently, our entire body has been programmed to be active physically. In the last 20 years, scientific research has increasingly shown that our ancient survival principle has beneficial effects not only on the cells and organs involved in physical activities but on the metabolism of the entire organism, influencing the homeostasis and integration of all bodily functions, likely stimulating the production of hormones and other regulatory molecules, with each affecting vital signalling pathways. Most of the web of factors involved in molecular signalling upon exercise are suspected to be centrally controlled by the brain, which has been reported to be deeply modified by physical activity. Such complexity requires a multifaceted approach to shed light on the molecular interactions that occur between physical activity and its outcome at a cellular level. 606 $aGenetics (non-medical)$2bicssc 610 $a?-actinin 610 $aaerobic exercise 610 $aantihypertensive therapy 610 $aBDNF 610 $abehavior 610 $ablood cell counts 610 $abody fat 610 $abody mass index 610 $abrain health 610 $aDNA-methylation 610 $aendurance 610 $aepigenetics 610 $aexercise 610 $aexercise and aging 610 $aexercise and health 610 $aexercise and neurodegeneration 610 $aferritin 610 $agene expression 610 $agenetics 610 $agenotyping 610 $aglucokinase-regulator 610 $agut microbiome 610 $agut microbiota 610 $ahealthy lifestyle 610 $ahepatic lipase 610 $ahigh-density lipoprotein 610 $ainflammation 610 $aintestinal microbiome 610 $aIrisin 610 $airon metabolism 610 $aketogenic diet 610 $aketogenic diet and fat 610 $alactate 610 $amarathon runners 610 $amyokines 610 $anatural killer cell 610 $aNK 610 $aobesity 610 $aPCBP1 610 $aPCBP2 610 $aperformance 610 $aphysical activity 610 $aphysical exercise 610 $asingle nucleotide polymorphism 610 $asingle nucleotide polymorphisms 610 $asport 610 $aTaiwan biobank 610 $aTaiwan Biobank 610 $aTFRC 615 7$aGenetics (non-medical) 700 $aDi Liegro$b Italia$4auth$01278675 906 $aBOOK 912 $a9910404084003321 996 $aGenetic and Epigenetic Modulation of Cell Functions by Physical Exercise$93013714 997 $aUNINA