LEADER 05082 am 22006733u 450 001 9910383156303321 005 20231107182527.0 010 $a981-13-2447-6 024 7 $a10.1007/978-981-13-2447-5 035 $a(CKB)4100000007334863 035 $a(DE-He213)978-981-13-2447-5 035 $a(MiAaPQ)EBC5626657 035 $a(Au-PeEL)EBL5626657 035 $a(OCoLC)1082684969 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/34120 035 $a(PPN)232962049 035 $a(EXLCZ)994100000007334863 100 $a20181227d2019 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAlternatives to Animal Testing$b[electronic resource] $eProceedings of Asian Congress 2016 /$fedited by Hajime Kojima, Troy Seidle, Horst Spielmann 205 $a1st ed. 2019. 210 $aSingapore$cSpringer Nature$d2019 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2019. 215 $a1 online resource (VI, 130 p. 46 illus., 39 illus. in color.) 311 $a981-13-2446-8 327 $a1. Zebrafish, Danio rerio as a replacement alternative model useful in CKDu experiments -- 2. Testing Method Development and Validation for In Vitro Skin Irritation Testing (SIT) by Using Reconstructed Human Epidermis (RhE) Skin Equivalent - EPiTR -- 3. Development the technique for the Preparation and Characterization of Reconstructed Human Epidermis (RHE) -- 4. Alternative Research (3Rs) in the World, Asia and Japan -- 5. Approaches to Reducing Animal Use for Acute Toxicity Testing: Retrospective Analyses of Pesticide Data -- 6. Progress in deleting the 1-year dog study for the safety assessment of pesticides -- 7. Cosmetic regulation and alternatives to animal experimentation in India -- 8. Guidance on the Use of Alternative Test Methods for the Safety Assessment of Cosmetics and Quasi-Drugs -- 9. Alternatives and Refinement for Animal Experimentation in Cancer Research -- 10. 3Rs in quality control of human vaccines: opportunities and barriers -- 11. The Use of Adverse Outcome Pathways (AOPs) to Support Chemical Safety Decisions within the Context of Integrated Approaches to Testing and Assessment (IATA) -- 12. Mechanism-based evaluation system for hepato- and nephrotoxicity or carcinogenicity using omics technology -- 13. Alternative methods for developmental toxicity testing using mouse ESCs -- 14. Futuristic approach to alternative model organisms: Hydra stakes its claim -- 15. The Lush Prize and Young Researcher Asia Awards 2016. 330 $aThis open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments ? replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0. 606 $aPharmacology 606 $aBiochemistry 606 $aAnimal welfare 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005 606 $aAnimal Welfare/Animal Ethics$3https://scigraph.springernature.com/ontologies/product-market-codes/H67010 610 $aMedicine 610 $aPharmacology 610 $aBiochemistry 610 $aAnimal welfare 615 0$aPharmacology. 615 0$aBiochemistry. 615 0$aAnimal welfare. 615 14$aPharmacology/Toxicology. 615 24$aBiochemistry, general. 615 24$aAnimal Welfare/Animal Ethics. 676 $a615 700 $aKojima$b Hajime$4edt$01356768 702 $aKojima$b Hajime$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSeidle$b Troy$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSpielmann$b Horst$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910383156303321 996 $aAlternatives to Animal Testing$93361649 997 $aUNINA