LEADER 04700nam 22008775 450 001 9910380750203321 005 20230125191100.0 010 $a3-030-33656-5 024 7 $a10.1007/978-3-030-33656-1 035 $a(CKB)4100000010480154 035 $a(DE-He213)978-3-030-33656-1 035 $a(MiAaPQ)EBC6120896 035 $a(Au-PeEL)EBL6120896 035 $a(OCoLC)1143621169 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/29538 035 $a(PPN)242976573 035 $a(EXLCZ)994100000010480154 100 $a20200220d2020 u| 0 101 0 $aeng 135 $aurnn#---mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGood Research Practice in Non-Clinical Pharmacology and Biomedicine /$fedited by Anton Bespalov, Martin C. Michel, Thomas Steckler 205 $a1st ed. 2020. 210 $cSpringer Nature$d2020 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (X, 423 p. 34 illus., 21 illus. in color.) 225 1 $aHandbook of Experimental Pharmacology,$x0171-2004 ;$v257 327 $a1. Quality in Non-GxP Research Environment -- 2. Guidelines & Initiatives for Good Research Practice -- 3. Learning from principles of evidence-based medicine to optimize nonclinical research practices -- 4. General Principles of Preclinical Study Design -- 5. Resolving the tension between exploration and confirmation in preclinical biomedical research -- 6. Blinding and Randomization -- 7. Out of control? Managing baseline variability in experimental studies with control groups -- 8. Quality of Research Tools -- 9. Genetic background and sex: impact on generalizability of research findings in pharmacology studies -- 10. Building robustness intro translational research -- 11. Minimum information and quality standards for conducting, reporting, and organizing in vitro research -- 12. Minimum Information in In Vivo Research -- 13. A reckless guide to P-values: Local evidence, global errors -- 14. Electronic Lab Notebooks and Experimental Design Assistants -- 15. Data storage -- 16. Design of meta-analysis studies -- 17. Publishers? responsibilities in promoting data quality and reproducibility -- 18. Quality governance in biomedical research -- 19. Good Research Practice ? Lessons from Animal Care & Use -- 20. Research collaborations and quality in research: foes or friends? -- 21. Costs of implementing quality in research practice. 330 $aThis open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine. 410 0$aHandbook of Experimental Pharmacology ;$v257 606 $aPharmacology 606 $aNeurosciences 606 $aCardiology 606 $aOncology   606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aCardiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33037 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 610 $aPharmacology/Toxicology 610 $aNeurosciences 610 $aCardiology 610 $aOncology 610 $aPharmacology 610 $aNeuroscience 610 $aInternal Medicine 610 $areproducibility 610 $astudy design 610 $adata analysis 610 $adata reporting 610 $adata integrity 610 $aquality management 610 $aopen access 610 $aCardiovascular medicine 615 0$aPharmacology. 615 0$aNeurosciences. 615 0$aCardiology. 615 0$aOncology  . 615 14$aPharmacology/Toxicology. 615 24$aNeurosciences. 615 24$aCardiology. 615 24$aOncology. 676 $a615 676 $a615.1072 700 $aBespalov$b Anton$4edt$01356373 702 $aBespalov$b Anton$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMichel$b Martin C$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSteckler$b Thomas$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910380750203321 996 $aGood Research Practice in Non-Clinical Pharmacology and Biomedicine$93360860 997 $aUNINA