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010   $a3-030-40464-1
024 7 $a10.1007/978-3-030-40464-2
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035   $a(DE-He213)978-3-030-40464-2
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035   $a(PPN)242979009
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100   $a20200206d2020      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aCurrent Applications of Pharmaceutical Biotechnology /$fedited by Ana Catarina Silva, João Nuno Moreira, José Manuel Sousa Lobo, Hugo Almeida
205   $a1st ed. 2020.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020.
215   $a1 online resource (VIII, 400 p. 80 illus., 24 illus. in color.) 
225 1 $aAdvances in Biochemical Engineering/Biotechnology,$x1616-8542 ;$v171
311 08$a3-030-40463-3 
327   $aIndustrial Challenges of Recombinant Proteins -- Insights on the Formulation of Recombinant Proteins -- Therapeutic Antibody Engineering and Selection Strategies -- Cytokines and Growth Factors -- Hormones, Blood Products and Therapeutic Enzymes -- Advances in Vaccines -- Human Pluripotent Stem Cells: Applications and Challenges for Regenerative Medicine and Disease Modeling -- Addressing the Manufacturing Challenges of Cell-Based Therapies -- Bioprinting Technologies in Tissue Engineering -- Gene Therapy -- The Impact of Pharmacogenomics in Personalized Medicine.
330   $aThis book offers an authoritative review of biopharmaceuticals and their clinical relevance. Biopharmaceuticals have been showing high therapeutic potential by means of biological and biosimilar medicines, particularly for the treatment of cancer, chronic diseases (e.g. diabetes, Crohn's disease, psoriasis and rheumatoid arthritis), neurodegenerative disorders (e.g. multiple sclerosis), and they have also been contributing to the progress of innovative therapies such as assisted reproductive medicine. Since the eighties, several biopharmaceuticals have been approved and, due to patents expiration, many biosimilars are also marketed. In this book, readers will find the most relevant updated information about the main clinical applications of pharmaceutical biotechnology. The authors provide expert analysis about the industrial challenges of recombinant proteins and the different classes of biopharmaceuticals, including monoclonal antibodies, vaccines, growth factorsand stem cells. Topics such as bioprinting technologies in tissue engineering, gene therapy and personalized medicine are also covered in this book. Professionals, students and researchers interested in this field will find this work an important account.
410  0$aAdvances in Biochemical Engineering/Biotechnology,$x1616-8542 ;$v171
606   $aBiotechnology
606   $aProteins
606   $aPharmaceutical chemistry
606   $aChemistry, Technical
606   $aRegenerative medicine
606   $aMedical genetics
606   $aBiotechnology
606   $aProtein Biochemistry
606   $aPharmaceutics
606   $aIndustrial Chemistry
606   $aRegenerative Medicine and Tissue Engineering
606   $aMedical Genetics
615  0$aBiotechnology.
615  0$aProteins.
615  0$aPharmaceutical chemistry.
615  0$aChemistry, Technical.
615  0$aRegenerative medicine.
615  0$aMedical genetics.
615 14$aBiotechnology.
615 24$aProtein Biochemistry.
615 24$aPharmaceutics.
615 24$aIndustrial Chemistry.
615 24$aRegenerative Medicine and Tissue Engineering.
615 24$aMedical Genetics.
676   $a615.19
676   $a615.19
702   $aSilva$b Ana Catarina$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aMoreira$b Joa?o Nuno$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aLobo$b Jose? Manuel Sousa$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aAlmeida$b Hugo$4edt$4http://id.loc.gov/vocabulary/relators/edt
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910380729103321
996   $aCurrent Applications of Pharmaceutical Biotechnology$92537968
997   $aUNINA