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024 7 $a10.1007/978-3-030-38692-4
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035   $a(DE-He213)978-3-030-38692-4
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100   $a20200229d2020      uy         0
101 0 $aeng
135   $aurnn#008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aTotal marrow irradiation $ea comprehensive review /$fedited by Jeffrey Y. C. Wong, Susanta K. Hui
205   $a1st ed. 2020.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020.
215   $a1 online resource (VI, 196 p.) $c45 illus., 38 illus. in color
311 0 $a3-030-38691-0 
327   $aImage Guided Total Marrow Irradiation: Past, Present and Future Directions -- Guidelines for Planning, Organ Dose Constraints and Treatment Delivery: A Systematic Review -- Radiobiologic Factors to Consider with Total Marrow Irradiation -- Dose Escalation of Total Marrow Irradiation in Advanced Acute Leukemia -- Reduced Intensity Conditioning Regimens in Combination with Total Marrow and Lymphoid Irradiation -- The Use of Total Marrow and Lymphoid Irradiation in Patients Undergoing Haplo-identical Transplants -- Combining the Benefits of Total Marrow Irradiation and ATG -- Dose Escalation of Total Marrow Irradiation in Multiple Myeloma -- Total Marrow Irradiation in Multiple Myeloma Undergoing Tandem Transplant -- Total Marrow and Lymphoid Irradiation in Non-Hodgkin?s Lymphoma -- Linac-based Total Marrow Irradiation -- The Case for Larger Fraction Sizes -- Acute and Late Toxicities With Total Marrow Irradiation: A Comparison to Standard Total Body Irradiation -- Total Body Irradiation Using Intensity Modulated Radiation Therapy.
330   $aThis book, written by a team of international experts, concisely reviews the rationale and clinical application of image-guided total marrow irradiation, a rapidly emerging area in radiation oncology and hematopoietic cell transplantation. The aim is to provide the practicing radiation oncologist, hematologist, medical physicist, and bone marrow transplant researcher with a fundamental understanding of key aspects and an appreciation of the increasing significance of total marrow irradiation as conditioning for bone marrow transplantation. Detailed attention is paid to the impacts of recent advances in radiation therapy technology, functional PET and MRI, and understanding of the response of bone marrow to radiation. Full consideration is also given to the ways in which technological advances in image-guided radiation therapy have created new opportunities to treat bone marrow transplant patients with limited transplant options due to advanced disease, age, or co-morbidities. Further topics covered include the ways in which cancer stem cells and the marrow microenvironment influence response to radiation therapy and the implementation of new-generation predictive radiobiologic factors in the clinic.
606   $aBone marrow$xRadiotherapy
606   $aBone marrow purging
606   $aRadiotherapy
615  0$aBone marrow$xRadiotherapy.
615  0$aBone marrow purging.
615  0$aRadiotherapy.
676   $a612.416
702   $aWong$b Jeffrey Y. C.$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aHui$b Susanta K.$4edt$4http://id.loc.gov/vocabulary/relators/edt
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906   $aBOOK
912   $a9910380726303321
996   $aTotal Marrow Irradiation$92184214
997   $aUNINA