LEADER 03660nam 22005535 450 001 9910373945403321 005 20230209161306.0 010 $a3-030-35213-7 024 7 $a10.1007/978-3-030-35213-4 035 $a(CKB)4100000010119004 035 $a(DE-He213)978-3-030-35213-4 035 $a(MiAaPQ)EBC6028040 035 $a(PPN)242848621 035 $a(EXLCZ)994100000010119004 100 $a20200124d2020 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBeyond Our Genes $ePathophysiology of Gene and Environment Interaction and Epigenetic Inheritance /$fedited by Raffaele Teperino 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (VIII, 266 p. 11 illus., 10 illus. in color.) 311 $a3-030-35212-9 320 $aIncludes bibliographical references and index. 327 $aSection I: The physiology of the gene/environment interaction -- Nutrition -- Physical Exercise -- Circadian Rhythm -- Toxicants: Smoke, Alcohol and Heavy Metals -- Hormones -- Section II: Gene-Environment Interaction and Disease Susceptibility -- Obesity and Metabolic Syndromes -- Cancer -- Neurological and Psychiatric Disorders -- Asthma and allergic disorders -- Lamarck Versus Darwin: The Concept of Acquired Epigenetic Inheritance -- Section III: Genome/Epigenome -- Genetic Contribution to Epigenetic Inheritance -- The Controversial Role of DNA Methylation in Epigenetic Inheritance -- Small Non-Coding RNAs -- Chromatin Modifiers -- Soma-to-Germline Information Transfer: Questions and Promises. 330 $aThe genotype/phenotype dichotomy is being slowly replaced by a more complex relationship whereby the majority of phenotypes arise from interactions between one?s genotype and the environment in which one lives. Interestingly, it seems that not only our lives, but also our ancestors? lives, determine how we look. This newly recognized form of inheritance is known as (epi)genetic, as it involves an additional layer of information on top of the one encoded by the genes. Its discovery has constituted one of the biggest paradigm shifts in biology in recent years. Understanding epigenetic factors may help explain the pathogenesis of several complex human diseases (such as diabetes, obesity and cancer) and provide alternative paths for disease prevention, management and therapy. This book introduces the reader to the importance of the environment for our own health and the health of our descendants, sheds light on the current knowledge on epigenetic inheritance and opens a window to future developments in the field. 606 $aHuman genetics 606 $aGenetics 606 $aGenetic engineering 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aGenetics and Genomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L32000 606 $aGenetic Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/C12037 615 0$aHuman genetics. 615 0$aGenetics. 615 0$aGenetic engineering. 615 14$aHuman Genetics. 615 24$aGenetics and Genomics. 615 24$aGenetic Engineering. 676 $a573.21 702 $aTeperino$b Raffaele$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910373945403321 996 $aBeyond Our Genes$92287911 997 $aUNINA