LEADER 05545nam 22005295 450 001 9910373921403321 005 20250609111226.0 010 $a3-030-23158-5 024 7 $a10.1007/978-3-030-23158-3 035 $a(CKB)4100000009759071 035 $a(DE-He213)978-3-030-23158-3 035 $a(MiAaPQ)EBC5972838 035 $a(PPN)260305243 035 $a(MiAaPQ)EBC5972629 035 $a(EXLCZ)994100000009759071 100 $a20191104d2019 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHeat Shock Protein 90 in Human Diseases and Disorders /$fedited by Alexzander A. A. Asea, Punit Kaur 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019. 215 $a1 online resource (XI, 607 p. 102 illus., 73 illus. in color.) 225 1 $aHeat Shock Proteins,$x1877-1246 ;$v19 311 08$a3-030-23157-7 327 $aSECTION I: ONCOGENIC ASPECTS OF HSP90 -- Chapter 1. Regulatory Roles of HSP90-rich Extracellular Vesicles -- Chapter 2. HSP90-Based Heterocomplex as Essential Regulator for Cancer Disease -- Chapter 3. Therapeutic Potential of Heat Shock Protein 90 Inhibitors in Colorectal Cancer -- Chapter 4. Hsp90 in the Migration of Primordial Germ Cells: A Model to Study Long-Distance Cell Migration and Perhaps Cancer? -- Chapter 5. Role of Heat Shock Protein 90 in Mammary Tumorigenesis -- Chapter 6. Role of HSP90 Inhibitors in the Treatment of Cancer -- Chapter 7. p53-HSP90 Axis in Human Cancer -- Chapter 8. HSP90 and its Inhibitors for Cancer Therapy: Use of Nano-delivery System to Improve its Clinical Application -- Chapter 9. Hsp90 is a Pivotal Player in Retinal Disease and Cancer -- Chapter 10. Targeting Hsp-90 Related Disease Entities for Therapeutic Development -- Chapter 11. HSP90: A Key Player in Metal-Induced Carcinogenesis? -- Section II: Biomolecular Aspects of HSP90 -- Chapter 12. Hsp90 and its Role in Heme-Maturation of Client Proteins: Implications for Human Diseases -- Chapter 13. Moonlighting Functions of Heat Shock Protein 90 -- Chapter 14. Hsp90 as a Member of Dicarboxylate Clamp TPR Protein Interaction Network: Implication in Human Diseases and Prospect as a Drug Target -- Chapter 15. ?Complex World? of Hsp90 Co-chaperone R2TP -- Chapter 16. Functions of SGT1, a Co-chaperone -- Chapter 17. Sti1/Hop Plays a Pivotal Role in Hsp90 Regulation beyond Bridging Hsp70 -- Section III: HSP90 in Natural Products Development.-Chapter 18. Hsp90: A Target for Susceptibilities and Substitutions in Biotechnological and Medicinal Application -- Chapter 19. Screening Technique for Heat Shock Protein 90 Inhibitors from Natural Products -- Chapter 20. Therapeutic Effects and Related Molecular Mechanisms of Celastrol, a Triterpenoid Natural Compound and Novel HSP90 Inhibitor Extracted from Plants of the Celastraceae Family -- Section IV: Clinical Aspects of HSP90 -- Chapter 21. Hsp90 Chaperone in Disease -- Chapter 22. Theranostic Implications of Heat Shock Proteins in Idiopathic Pulmonary Fibrosis -- Chapter 23. Heat Shock Protein 90 and Reproduction in Female Animals: Ovary, Oocyte and Early Embryo -- Chapter 24. Heat Shock Protein 90 in Severe Trauma -- Chapter 25. HSP90 - Is there an Unknown Role in Pain Neurobiology -- Chapter 26. Heat Shock Protein 90 in Kidney Stone Disease -- Chapter 27. HSP90 et al. - Chaperome and Proteostasis Deregulation in Human Disease. 330 $aThe book Heat Shock Protein 90 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP90. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, previously unknown signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding Oncogenic Aspects of HSP90; Section II, focuses on Bimolecular Aspects of HSP90; Section III, emphasizes and HSP90 in Natural Products Development and Section IV; give the most up to date reviews on Clinical Aspects of HSP90. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Natural Products, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery. 410 0$aHeat Shock Proteins,$x1877-1246 ;$v19 606 $aProteins 606 $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040 606 $aProteïnes$2thub 608 $aLlibres electrònics$2thub 615 0$aProteins. 615 14$aProtein Science. 615 $aProteïnes 676 $a572.6 702 $aAsea$b Alexzander A. A.$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aKaur$b Punit$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910373921403321 996 $aHeat Shock Protein 90 in Human Diseases and Disorders$92287908 997 $aUNINA