LEADER 05020nam 22007815 450 001 9910373921103321 005 20240118131756.0 010 $a1-4939-9802-1 024 7 $a10.1007/978-1-4939-9802-9 035 $a(CKB)4100000009759133 035 $a(DE-He213)978-1-4939-9802-9 035 $a(MiAaPQ)EBC5972842 035 $a(PPN)24860516X 035 $a(EXLCZ)994100000009759133 100 $a20191105d2019 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aOmics Approaches to Understanding Muscle Biology /$fedited by Jatin George Burniston, Yi-Wen Chen 205 $a1st ed. 2019. 210 1$aNew York, NY :$cSpringer US :$cImprint: Springer,$d2019. 215 $a1 online resource (VII, 217 p. 35 illus., 32 illus. in color.) 225 1 $aMethods in Physiology,$x2628-7471 311 $a1-4939-9801-3 327 $aPart I: Genomic and Epi-genomic -- 1) GWAS/muscle function and diseases (by Eric Hoffman) -- 2) Whole genome and whole exon sequencing/muscle disorders (by Silvère van der Maarel and Richard Lemmers) -- 3) Epi-genome approaches/muscle regeneration (by Vittorio Sartorelli) -- Part II: Transcriptomic -- 4) RNA profiling (by Yi-Wen Chen, confirmed) -- 5) miRNA profiling (by Alyson Fiorillo) -- 6) Single cell profiling in muscle (byPier Lorenzo Puri) -- 7) Statistics and bioinformatics (by Heather Gordish) -- Part III: Proteomic -- 8). Proteome profiling of human/ clinical samples ? i.e. necessarily label-free techniques (by Lawrence Mandarino) -- 9) Proteome profiling of cell and animal models ? i.e. label techniques such as SILAC (by Matthias Mann OR SILAM with JR Yates III) -- 10) Global analysis of post-translational modifications (by David E James) -- 11) Proteome dynamics ? synthesis and degradation on a proteome wide scale (by Jatin Burniston, confirmed) -- Part IV: Metabolomic -- 12) Non-targeted metabolomics using mass spectrometry (by Charles Burant). 330 $aThis book is a collection of principles and current practices in omics research, applied to skeletal muscle physiology and disorders. The various sections are categorized according to the level of biological organization, namely, genomics (DNA), transcriptomics (RNA), proteomics (protein), and metabolomics (metabolite). With skeletal muscle as the unifying theme, and featuring contributions from leading experts in this traditional field of research, it highlights the importance of skeletal muscle tissue in human development, health and successful ageing. It also discusses other fascinating topics like developmental biology, muscular dystrophies, exercise, insulin resistance and atrophy due to disuse, ageing or other muscle diseases, conveying the vast opportunities for generating new hypotheses as well as testing existing hypotheses by combining high-throughput techniques with proper experiment designs, bioinformatics and statistical analyses. Presenting the latest research techniques, this book is a valuable resource for the physiology community, particularly researchers and grad students who want to explore the new opportunities for omics technologies in basic physiology research. 410 0$aMethods in Physiology,$x2628-7471 606 $aHuman physiology 606 $aProteomics 606 $aMetabolism 606 $aHuman genetics 606 $aSystems biology 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 606 $aProteomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L1403X 606 $aMetabolomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L15030 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aSystems Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L15010 606 $aMúsculs$2thub 606 $aFisiologia humana$2thub 606 $aMalalties musculars$2thub 606 $aGenètica molecular humana$2thub 608 $aLlibres electrònics$2thub 615 0$aHuman physiology. 615 0$aProteomics. 615 0$aMetabolism. 615 0$aHuman genetics. 615 0$aSystems biology. 615 14$aHuman Physiology. 615 24$aProteomics. 615 24$aMetabolomics. 615 24$aHuman Genetics. 615 24$aSystems Biology. 615 7$aMúsculs 615 7$aFisiologia humana 615 7$aMalalties musculars 615 7$aGenètica molecular humana 676 $a612 702 $aBurniston$b Jatin George$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aChen$b Yi-Wen$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910373921103321 996 $aOmics Approaches to Understanding Muscle Biology$92212331 997 $aUNINA