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100   $a20191113d2019      u|         0
101 0 $aeng
135   $aurnn#008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
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200 10$aActin Polymerization in Apicomplexan $eA Structural, Functional and Evolutionary Analysis /$fedited by Avinash Kale
205   $a1st ed. 2019.
210  1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2019
215   $a1 online resource (XI, 101 p. 11 illus. in color.)
311   $a981-13-7449-X 
320   $aIncludes bibliographical references.
327   $aChapter 1. Synthesis and Characterization of nano Apicomplexan motility: A cellular perspective particles -- Chapter 2. Introduction: Gliding Motility- The model and the mechanism -- Chapter 3. Actin: The central ubiquitous player in the phenomenon -- Chapter 4. Formin: The multidomain elongator of polymer -- Chapter 5. Profilin: The associates of Formin -- Chapter 6. ADF (Actin Depolymerizing Factor): The breaker of the polymer in homeostasis -- Chapter 7. Cyclase associated protein (CAP): The silent worker -- Chapter 8. Capping Protein (CP): The formin competitor -- Chapter 9. Coronin: An Overview -- Chapter 10. Mathematical Model: A revelation of synergistic cross talks between the actin regulators -- Chapter 11. Evolution: The hallmarks of Gliding motility in apicomplexan.
330   $aThis book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements. The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CP? and CP?), cyclase-associated protein (CAP) and coronin 13?24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design. Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.
606   $aEnginyeria de proteïnes$2thub
606   $aParasitology
606   $aBiomechanics
606   $aProteins 
606   $aBioinformatics
606   $aParasitology$3https://scigraph.springernature.com/ontologies/product-market-codes/B19002
606   $aBiomechanics$3https://scigraph.springernature.com/ontologies/product-market-codes/L29020
606   $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040
606   $aProtein Structure$3https://scigraph.springernature.com/ontologies/product-market-codes/L14050
606   $aBioinformatics$3https://scigraph.springernature.com/ontologies/product-market-codes/L15001
608   $aLlibres electrònics$2thub
615  7$aEnginyeria de proteïnes
615  0$aParasitology.
615  0$aBiomechanics.
615  0$aProteins .
615  0$aBioinformatics.
615 14$aParasitology.
615 24$aBiomechanics.
615 24$aProtein Science.
615 24$aProtein Structure.
615 24$aBioinformatics.
676   $a616.96
702   $aKale$b Avinash$4edt$4http://id.loc.gov/vocabulary/relators/edt
801  0$bMiAaPQ
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906   $aBOOK
912   $a9910373917803321
996   $aActin Polymerization in Apicomplexan$91912463
997   $aUNINA