LEADER 04373nam 22006495 450 001 9910373916903321 005 20220314151420.0 010 $a981-329-717-4 024 7 $a10.1007/978-981-32-9717-3 035 $a(CKB)4100000009844763 035 $a(DE-He213)978-981-32-9717-3 035 $a(MiAaPQ)EBC5983832 035 $a(PPN)242824064 035 $a(EXLCZ)994100000009844763 100 $a20191122d2019 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCo-signal Molecules in T Cell Activation $eImmune Regulation in Health and Disease /$fedited by Miyuki Azuma, Hideo Yagita 205 $a1st ed. 2019. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2019. 215 $a1 online resource (VI, 326 p. 22 illus., 21 illus. in color.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1189 311 $a981-329-716-6 327 $aPart I: Basic Understanding of Co-signal Molecules in T cell activation -- Chapter 1 Co-signal molecules in T cell activation -- Chapter 2 The CD28-B7 family of co-signaling molecules -- Chapter 3 The TNF YNFR family of co-signal molecules -- Chapter 4 Signal transduction via co-stimulatory and co-inhibitory receptors -- Chapter 5 Molecular dynamics of co-signal molecules in t cell activation -- Chapter 6 Role of co-stimulatory molecules in T helper cell differentiation -- Chapter 7 Control of regulatory T cells by co-signal molecules -- Part II: Co-signal Molecules in Health and Disease -- Chapter 8 Stimulatory and inhibitory co-signals in autoimmunity -- Chapter 9 Co-signaling molecules in neurological diseases -- Chapter 10 Costimulation blockade in transplantation -- Chapter 11 Immunotherapy targeting co-signal molecules. . 330 $aThis book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science. . 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1189 606 $aImmunology 606 $aCancer research 606 $aNeurology  606 $aOncology   606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aNeurology$3https://scigraph.springernature.com/ontologies/product-market-codes/H36001 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 606 $aCèl·lules T$2thub 606 $aImmunologia$2thub 608 $aLlibres electrònics$2thub 615 0$aImmunology. 615 0$aCancer research. 615 0$aNeurology . 615 0$aOncology  . 615 14$aImmunology. 615 24$aCancer Research. 615 24$aNeurology. 615 24$aOncology. 615 7$aCèl·lules T 615 7$aImmunologia 676 $a616.079 702 $aAzuma$b Miyuki$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aYagita$b Hideo$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910373916903321 996 $aCo-signal Molecules in T Cell Activation$92140623 997 $aUNINA