LEADER 05153nam 22007095 450 001 9910373910803321 005 20250609111011.0 010 $a981-329-636-4 024 7 $a10.1007/978-981-32-9636-7 035 $a(CKB)4100000009939745 035 $a(MiAaPQ)EBC5984572 035 $a(DE-He213)978-981-32-9636-7 035 $a(PPN)25311604X 035 $a(MiAaPQ)EBC5984512 035 $a(EXLCZ)994100000009939745 100 $a20191123d2019 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMyelin $eBasic and Clinical Advances /$fedited by Kazunori Sango, Junji Yamauchi, Toru Ogata, Keiichiro Susuki 205 $a1st ed. 2019. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2019. 215 $a1 online resource (xi, 378 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1190 311 08$a981-329-638-0 311 08$a981-329-635-6 327 $aPart 1. Myelination in neural development and regeneration -- 1. Cellular signal-regulated Schwann cell myelination and remyelination -- 2. Regulatory mechanism of peripheral nerve myelination by glutamate-induced signaling -- 3. Cytoskeletal signal-regulated oligodendrocyte myelination and remyelination -- 4. Activity-dependent myelination -- 5. Heterogeneity of oligodendrocytes and their precursor cells -- Part 2. Specialized structures along the myelinated nerve fibers -- 6. Functional domains in myelinated axons -- 7. Physiology of myelinated nerve conduction and pathophysiology of demyelination -- 8. Under the ECM dome: the physiological role of the perinodal extracellular matrix as an ion diffusion barrier -- 9. Oligodendrocyte physiology modulating axonal excitability and nerve conduction -- 10. Mitochondrial dynamics in physiology and pathology of myelinated axons -- 11. The role of sulfatides in axon-glia interactions -- 12. Structures and molecular composition of Schmidt-Lanterman incisures -- Part 3. Myelin pathology in the central nervous system -- 13. Pelizaeus-Merzbacher disease: molecular and cellular pathologies and associated phenotypes -- 14. Multiple sclerosis -- 15. Visualization of myelin for the diagnosis and treatment monitoring of multiple sclerosis -- 16. Roads to formation of normal myelin structure and pathological myelin structure -- 17. Therapeutic strategies for oligodendrocyte-mediated remyelination -- 18. Brain tumors of glial cell origin -- Part 4. Myelin pathology in the peripheral nervous system -- 19. Schwann cell and the pathogenesis of Charcot-Marie-Tooth disease -- 20. Guillain- Barré Syndrome -- 21. Chronic inflammatory demyelinating polyneuropathy -- 22. Schwann cells as crucial players in diabetic neuropathy -- 23. Drug-induced demyelinating neuropathies -- 24. Transthyretin amyloid neuropathy: the Schwann cell hypothesis. 330 $aThis book presents the latest exciting advances in understanding of the structure and function of myelin in the central and peripheral nervous systems under normal and pathological conditions. Readers will find state of the art information from the perspectives of both basic neuroscience and clinical neurology and neuropathology. Detailed attention is paid to the findings and implications of recent research on the myelin-forming glial cells such as oligodendrocytes and Schwann cells. The discussion of myelin pathology encompasses a wide range of diseases and conditions, including, for example, multiple sclerosis, Pelizaeus-Merzbacher disease, traumatic brain and spinal cord injuries, brain tumors of glial cell origin, Charcot-Marie-Tooth disease, immune-mediated neuropathy, and diabetic neuropathy. The authors comprise researchers at the cutting edge of biotechnology and experts in the diseases discussed. The clearly written text is supported by numerous high-quality light and electron microscopy, CT, and MR images. 410 0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1190 606 $aNeurosciences 606 $aNeurology 606 $aBiochemistry 606 $aNeuroscience 606 $aNeurology 606 $aBiochemistry 606 $aMielina$2thub 606 $aSistema nerviós$2thub 606 $aNeurociències$2thub 608 $aLlibres electrònics$2thub 615 0$aNeurosciences. 615 0$aNeurology. 615 0$aBiochemistry. 615 14$aNeuroscience. 615 24$aNeurology. 615 24$aBiochemistry. 615 7$aMielina 615 7$aSistema nerviós 615 7$aNeurociències. 676 $a612.81 702 $aSango$b Kazunori$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aYamauchi$b Junji$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aOgata$b Toru$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSusuki$b Keiichiro$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910373910803321 996 $aMyelin$91994035 997 $aUNINA