LEADER 04822nam 22005415 450 001 9910373909003321 005 20220323164331.0 010 $a3-030-32459-1 024 7 $a10.1007/978-3-030-32459-9 035 $a(CKB)4100000009939799 035 $a(MiAaPQ)EBC5986155 035 $a(DE-He213)978-3-030-32459-9 035 $a(PPN)258064838 035 $a(EXLCZ)994100000009939799 100 $a20191126d2019 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHIV/AIDS: Immunochemistry, Reductionism and Vaccine Design $eA Review of 20 Years of Research /$fby Marc H V Van Regenmortel 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019 215 $a1 online resource (379 pages) 311 $a3-030-32458-3 327 $aPart I.Immunochemistry -- 1 What is a B cell epitope -- 2 Molecular design versus empirical discovery in peptide-based vaccines. Coming to terms with fuzzy recognition sites and ill-defined structure?function relationships in immunology -- 3 Synthetic Peptide Vaccines and the Search for Neutralization B Cell Epitopes -- 4 Specificity, polyspecificity, and heterospecificity of antibody?antigen recognition -- Part II. Reductionism -- 5 Reductionism and the search for structure?function relationships in antibody molecules -- 6 Reductionism and complexity in molecular biology -- 7 Editorial: Biological complexity emerges from the ashes of genetic reductionism -- 8 The rational design of biological complexity: A deceptive metaphor., 9 Basic research in HIV vaccinology is hampered by reductionist thinking -- 10 Commentary: Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinking -- 11 Nature and Consequences of Biological Reductionism for the Immunological Study of Infectious Diseases., Part III. Vaccinology -- 12 Limitations to the structure?based design of HIV?1 vaccine immunogens -- 13 Two meanings of reverse vaccinology and the empirical nature of vaccine science -- 14 Requirements for empirical immunogenicity trials, rather than structure-based design, for developing an effective HIV vaccine -- 15 Paradigm Changes and the Future of HIV Vaccine Research: A Summary of a Workshop Held in Baltimore on 20 November 2013 -- 16 Editorial: Paradigm changes are required in HIV vaccine research -- 17 An outdated notion of antibody specificity is one of the major detrimental assumptions of the structure-based reverse vaccinology paradigm, which prevented it from helping to develop an effective HIV-1 vaccine -- 18 More surprises in the development of an HIV vaccine -- 19 Why Does the Molecular Structure of Broadly Neutralizing Monoclonal Antibodies Isolated from Individuals Infected with HIV-1 not Inform the Rational Design of an HIV-1 Vaccine? -- 20 Old and New Concepts and Strategies in HIV Vaccinology: A Report from a Workshop held in Rome on 17 June 2016 -- 21 Structure-Based Reverse Vaccinology Failed in the Case of HIV Because it Disregarded Accepted Immunological Theory -- 22 Immune systems rather than antigenic epitopes elicit and produce protective antibodies against HIV -- 23 Development of a Preventive HIV Vaccine Requires Solving Inverse Problems Which Is Unattainable by Rational Vaccine Design -- 24 Viral species, viral genomes and HIV vaccine design: is the rational design of biological complexity a utopia? 330 $aThis book gathers a series of pivotal papers on the development of an HIV/AIDS vaccine published in the last two decades. Accompanied by extensive comments putting the material into an up-to-date context, all three parts of the book offer a broad overview of the numerous unsuccessful attempts made in recent years to develop a preventive HIV vaccine. Providing a detailed review and analysis of studies published from 1998 to the present day, it examines the likely reasons for the failure to develop an HIV vaccine despite multi-million dollar investments. 606 $aVaccines 606 $aVirology 606 $aVaccine$3https://scigraph.springernature.com/ontologies/product-market-codes/B16010 606 $aVirology$3https://scigraph.springernature.com/ontologies/product-market-codes/B22003 606 $aVIH (Virus)$2thub 608 $aLlibres electrònics$2thub 615 0$aVaccines. 615 0$aVirology. 615 14$aVaccine. 615 24$aVirology. 615 7$aVIH (Virus) 676 $a616.979206 676 $a616.9792 700 $aVan Regenmortel$b Marc H V$4aut$4http://id.loc.gov/vocabulary/relators/aut$0938709 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK9 912 $a9910373909003321 996 $aHIV$92115746 997 $aUNINA