LEADER 03736nam 22005655 450 001 9910373908003321 005 20251116225021.0 010 $a3-030-35362-1 024 7 $a10.1007/978-3-030-35362-9 035 $a(CKB)4100000010011897 035 $a(MiAaPQ)EBC6001559 035 $a(DE-He213)978-3-030-35362-9 035 $a(PPN)242817238 035 $a(EXLCZ)994100000010011897 100 $a20191224d2019 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aConcepts and Principles of Pharmacology $e100 Years of the Handbook of Experimental Pharmacology /$fedited by James E. Barrett, Clive P. Page, Martin C. Michel 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019. 215 $a1 online resource (viii, 466 pages) $cillustrations 225 1 $aHandbook of Experimental Pharmacology,$x0171-2004 ;$v260 311 08$a3-030-35361-3 320 $aIncludes bibliographical references. 327 $aPart 1. A Century of Advances in Pharmacology -- 1. Perspectives of Pharmacology Over the Past 100 years -- 2. Emergent concepts of receptor pharmacology -- 3. The Evolving Landscape of Cancer Therapeutics -- 4. Monoclonal Antibodies: Past, Present and Future -- 5. 100 years of Drug Delivery to the Lungs -- 6. Exploiting the Diversity of Ion Channels: Ion channel Pharmacology for Pain modulation -- 7. Exploiting the Diversity of Ion Channels: Modulation of Ion Channels for Therapeutic Indications -- Part 2. Recent developments and enabling technologies in pharmacology -- 8. Genetically Encoded Fluorescent Calcium and Voltage Indicators -- 9. Mechanistic Image-Based Modeling: Concepts and Applications of Image-Based Modeling -- 10. Pharmacometabonomics: The Prediction of Drug Effects Using Metabolic Profiling -- 11. The Microbiome and its Potential for Pharmacology -- 12. Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology -- Part 3. The future of pharmacology -- 13. The future of clinical trial design: The Transition from Hard Endpoints to Value-Based Endpoings -- 14. Placebos and the Placebo Effect in Drug Trials -- 15. Pharmacoepidemiology -- 16. Why are new drugs expensive and how can they stay affordable? . 330 $aCelebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy. 410 0$aHandbook of Experimental Pharmacology,$x0171-2004 ;$v260 606 $aPharmacology 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aPharmacology 606 $aFarmacologia$2thub 608 $aLlibres electrònics$2thub 615 0$aPharmacology. 615 14$aPharmacology/Toxicology. 615 7$aPharmacology 615 7$aFarmacologia. 676 $a615.7 702 $aBarrett$b James E.$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aPage$b C. P.$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMichel$b Martin C$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910373908003321 996 $aConcepts and principles of pharmacology$91765535 997 $aUNINA