LEADER 05638nam 22006975 450 001 9910373907803321 005 20220323201739.0 010 $a981-13-2218-X 024 7 $a10.1007/978-981-13-2218-1 035 $a(CKB)4100000010012062 035 $a(MiAaPQ)EBC5990218 035 $a(DE-He213)978-981-13-2218-1 035 $a(PPN)242817750 035 $a(EXLCZ)994100000010012062 100 $a20191205d2019 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aInsights into Human Neurodegeneration: Lessons Learnt from Drosophila /$fedited by Mousumi Mutsuddi, Ashim Mukherjee 205 $a1st ed. 2019. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2019. 215 $a1 online resource (470 pages) 311 $a981-13-2217-1 320 $aIncludes bibliographical references. 327 $aChapter 1. Introduction to Drosophila as a model organism -- Chapter 2. Methods for creating fly models in order to understand molecular mechanism of neurological diseases -- Chapter 3. Neurodegeneration: Lessons learnt from forward genetic screens in Drosophila -- Chapter 4. Drosophila neural stem cells, a primer for understanding mammalian neurobiology -- Chapter 5. Understanding motor disorders using flies -- Chapter 6. Metabolic alterations amalgamated with neurodegenerative diseases -- Chapter 7. Notch signalling in neurodegenerative disease -- Chapter 8. Drosophila model of neurofibrillar tangles -- Chapter 9. Unraveling Alzheimer's disease using Drosophila -- Chapter 10. Modelling Human Parkinson's disease in fly -- Chapter 11. Post-translational modifications: A mystery to unravel Huntington?s disease -- Chapter 12. Understanding the pathogenicity of non-coding RNA expansion associated neurodegenerative disorders -- Chapter 13. Expanding roles of RNA binding proteins in neurodegeneration -- Chapter 14. Hereditary Spastic Paraplegia Disease in Drosophila -- Chapter 15. Drosophila as a model system for the identification of pharmacological therapies in neurodegenerative diseases. 330 $aThis book is aimed at generating an updated reservoir of scientific endeavors undertaken to unravel the complicated yet intriguing topic of neurodegeneration. Scientists from Europe, USA and India who are experts in the field of neurodegenerative diseases have contributed to this book. This book will help readers gain insight into the recent knowledge obtained from Drosophila model, in understanding the molecular mechanisms underlying neurodegenerative disorders and also unravel novel scopes for therapeutic interventions. Different methodologies available to create humanized fly models that faithfully reflects the pathogenicities associated with particular disorders have been described here. It also includes information on the exciting area of neural stem cells. A brief discussion on neurofibrillary tangles, precedes the elaborate description of lessons learnt from Drosophila about Alzheimer's, Parkinson?s, Spinomuscular Atrophy, Huntington?s diseases, RNA expansion disorders and Hereditary Spastic Paraplegia. We have concluded the book with the use of Drosophila for identifying pharmacological therapies for neurodegenerative disorders. The wide range of topics covered here will not only be relevant for beginners who are new to the concept of the extensive utility of Drosophila as a model to study human disorders; but will also be an important contribution to the scientific community, with an insight into the paradigm shift in our understanding of neurodegenerative disorders. Completed with informative tables and communicative illustrations this book will keep the readers glued and intrigued. We have comprehensively anthologized the lessons learnt on neurodegeneration from Drosophila and have thus provided an insight into the multidimensional aspects of pathogenicities of majority of the neurodegenerative disorders. 606 $aNeurosciences 606 $aDevelopmental biology 606 $aAnimal models in research 606 $aStem cells 606 $aPosttranslational modification 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aDevelopmental Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L18000 606 $aAnimal Models$3https://scigraph.springernature.com/ontologies/product-market-codes/L25050 606 $aStem Cells$3https://scigraph.springernature.com/ontologies/product-market-codes/L16010 606 $aPosttranslational Modification$3https://scigraph.springernature.com/ontologies/product-market-codes/L14090 606 $aNeurociències$2thub 608 $aLlibres electrònics$2thub 615 0$aNeurosciences. 615 0$aDevelopmental biology. 615 0$aAnimal models in research. 615 0$aStem cells. 615 0$aPosttranslational modification. 615 14$aNeurosciences. 615 24$aDevelopmental Biology. 615 24$aAnimal Models. 615 24$aStem Cells. 615 24$aPosttranslational Modification. 615 7$aNeurociències 676 $a595.774 702 $aMutsuddi$b Mousumi$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMukherjee$b Ashim$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910373907803321 996 $aInsights into Human Neurodegeneration: Lessons Learnt from Drosophila$92184169 997 $aUNINA