LEADER 04739nam 22007095 450 001 9910373907703321 005 20240118134624.0 010 $a981-15-0557-8 024 7 $a10.1007/978-981-15-0557-7 035 $a(CKB)4100000010012065 035 $a(MiAaPQ)EBC5996870 035 $a(DE-He213)978-981-15-0557-7 035 $a(PPN)24281784X 035 $a(EXLCZ)994100000010012065 100 $a20191213d2019 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aZinc Signaling$b[electronic resource] /$fedited by Toshiyuki Fukada, Taiho Kambe 205 $a2nd ed. 2019. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2019. 215 $a1 online resource (412 pages) 311 $a981-15-0556-X 327 $a1 Opening The Second Era of Zinc Signaling study -- 2 Regulation of cellular zinc ions and their signalling functions -- 3 Zinc transporter proteins-A review and a new view from biochemistry -- 4 The Metallothionein-Zinc Landscape: How It Shapes Antimicrobial Immunity -- 5 Role of Zinc signaling in mast cell, basophil, T cell, and B cell -- 6 The role of Zinc signaling in reproduction -- 7 Zinc Signaling in Skeletal Muscle -- 8 Zinc Signaling in Aging Heart Function -- 9 Zinc signaling in the life and death of neurons -- 10 Possible therapeutic roles of metallothionein-3 and zinc in endosome-autophagosome-lysosomal pathway (EALP) dysfunction in astrocytes -- 11 Zinc in neurodegeneration -- 12 Role of Zinc Transporters in Type 2 Diabetes and Obesity -- 13 Zinc Signals in Immunology -- 14 Zinc Signals in Inflammation -- 15 Zinc transporters and zinc signaling in skin formation and diseases -- 16 Post-translational mechanisms of zinc signalling in cancer -- 17 Zinc Signaling (Zinc?in) in Intestinal function -- 18 In Situ Imaging of Zinc with Synthetic Fluorescent Probes -- 19 Zinc Signals in biology. 330 $aThis book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students. 606 $aMedicine 606 $aCell physiology 606 $aCell biology 606 $aBiochemistry 606 $aMedical biochemistry 606 $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X 606 $aCell Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L33010 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005 606 $aMedical Biochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/H35005 606 $aZinc en l'organisme$2thub 606 $aEfectes fisiològics$2thub 608 $aLlibres electrònics$2thub 615 0$aMedicine. 615 0$aCell physiology. 615 0$aCell biology. 615 0$aBiochemistry. 615 0$aMedical biochemistry. 615 14$aBiomedicine, general. 615 24$aCell Physiology. 615 24$aCell Biology. 615 24$aBiochemistry, general. 615 24$aMedical Biochemistry. 615 7$aZinc en l'organisme 615 7$aEfectes fisiològics 676 $a612.01524 702 $aFukada$b Toshiyuki$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aKambe$b Taiho$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910373907703321 996 $aZinc Signaling$91994032 997 $aUNINA