LEADER 04540nam 22006255 450 001 9910373907003321 005 20251116225017.0 010 $a3-030-28703-3 024 7 $a10.1007/978-3-030-28703-0 035 $a(CKB)4100000010013839 035 $a(MiAaPQ)EBC6000762 035 $a(DE-He213)978-3-030-28703-0 035 $a(PPN)242820115 035 $a(EXLCZ)994100000010013839 100 $a20191219d2019 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMolecular Genetics of Inflammatory Bowel Disease /$fedited by Charlotte Hedin, John D. Rioux, Mauro D'Amato 205 $a2nd ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019. 215 $a1 online resource (399 pages) 300 $aIncludes index. 311 08$a3-030-28702-5 327 $aPart 1: The Foundation of IBD Genetics, Human and Animal Studies -- A Primer on IBD: Phenotypes, Diagnosis, Treatment and Clinical Challenges -- Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies -- Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease -- Part 2: The Genetic and Molecular Makeup of Inflammatory Bowel Disease -- Complex Disease Genes and their Discovery -- The Genetics of Crohn's Disease -- Genetics of Ulcerative Colitis -- Genetic Overlap between Inflammatory Bowel Disease and Other Diseases -- Molecular Profiling of IBD Subtypes/Response to Therapy -- Epigenetics of Inflammatory Bowel Disease -- Part 3: Pathogenetic Pathways in Inflammatory Bowel Disease -- Nod1 and Nod2 and the Immune Response to Bacteria -- The IL-23-Th17 Axis in Intestinal Inflammation -- Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics -- The Epithelial Barrier -- Host Interactions with Bacteria: From ?Entente Cordiale? to ?Casus Belli? -- Cytokines in Inflammatory Bowel Disease -- Part 4: Concluding Remarks and Future Perspectives -- Towards Personalized Therapy in Inflammatory Bowel Disease -- Index. 330 $aInflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowledge, with particular focus on the molecular and genetic mechanisms at the basis of IBD. Invited experts, at the frontline of IBD research, introduce basic concepts in the pathophysiology of IBD and its two major forms Crohn?s disease and ulcerative colitis, provide a historical perspective and highlight latest discoveries of IBD genetic research, describe how this information has helped to unravel novel pathogenetic pathways, and formulate a vision for future investigations and their clinical application in IBD. State-of-the-art information contained in this book is an exceptional resource for all those in the biomedical field with a specific interest in IBD, including basic scientists, gastroenterologists, GI specialist doctors and research nurses, but also medical and biomedical students. 606 $aHuman genetics 606 $aMolecular biology 606 $aGastroenterology 606 $aMalalties inflamatòries intestinals$2thub 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aGastroenterology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33061 608 $aLlibres electrònics$2thub 615 0$aHuman genetics. 615 0$aMolecular biology. 615 0$aGastroenterology. 615 7$aMalalties inflamatòries intestinals 615 14$aHuman Genetics. 615 24$aMolecular Medicine. 615 24$aGastroenterology. 676 $a616.344 676 $a616.344042 702 $aHedin$b Charlotte$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aRioux$b John D.$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aD'Amato$b Mauro$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910373907003321 996 $aMolecular Genetics of Inflammatory Bowel Disease$91948514 997 $aUNINA