LEADER 04144nam 22006375 450 001 9910373904003321 005 20220511160000.0 010 $a981-15-1169-1 024 7 $a10.1007/978-981-15-1169-1 035 $a(CKB)4100000010121912 035 $a(DE-He213)978-981-15-1169-1 035 $a(MiAaPQ)EBC6027270 035 $a(PPN)242843522 035 $a(EXLCZ)994100000010121912 100 $a20200116d2019 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPeroxisomes: Biogenesis, Function, and Role in Human Disease /$fedited by Tsuneo Imanaka, Nobuyuki Shimozawa 205 $a1st ed. 2019. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2019 215 $a1 online resource (XII, 279 p. 65 illus., 33 illus. in color.) 311 $a981-15-1168-3 327 $aPart 1 Biogenesis and Function of peroxisome -- 1 The history of peroxisomal research -- 2 Peroxisome Biogenesis -- 3 Peroxisome Degradation and Its Molecular Machinery -- 4 The function of the peroxisome -- Part 2 Dysfunction of Peroxisome and Human Disease -- 5 Peroxisomal disorders -- 6 Model organisms used to understand peroxisomal disorders -- 7 Diagnosis of peroxisomal disorders -- 8 Therapeutic strategies for X-linked adrenoleukodystrophy, a representative peroxisome disease -- Part 3 Topics in Peroxisome Research -- 9 The isolation of peroxisomes -- 10 Structure Biology of peroxisomal proteins, peroxins -- 11 Lipidomics of peroxisomal disorders -- 12 Neurophysiology and neuropsychology for X-ALD. . 330 $aThis book provides readers with a comprehensive overview of peroxisomes and their role in human diseases. It starts by describing the history of peroxisome research and then examines in detail the current understanding of the biogenesis and function of peroxisomes. It then focuses on peroxisomal disorders and the involvement of peroxisomes in cancer and age-related diseases, discussing in detail the use of model organisms to elucidate the pathogenesis of peroxisomal disorders and the physiological importance of peroxisomal proteins. Further, the book examines diagnostic and therapeutic strategies in peroxisomal disorders as well as significant recent advances. Lastly, it addresses various topics in peroxisome research, including the isolation of peroxisomes from mammalian tissues and cells, the structural biology of peroxisomal proteins, the lipidomics of peroxisomal disorders, the value of exome sequencing, and neuropsychological testing in X-linked adrenoleukodystrophy. Given its scope, the book is a valuable resource for postgraduate students and researchers in the life sciences and clinicians in the fields of internal medicine, pediatrics, and neurology. 606 $aHuman physiology 606 $aCell biology 606 $aCell physiology 606 $aBioquímica$2thub 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aCell Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L33010 606 $aAnimal Biochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/L14013 606 $aMalalties$2thub 608 $aLlibres electrònics$2thub 615 0$aHuman physiology. 615 0$aCell biology. 615 0$aCell physiology. 615 7$aBioquímica 615 14$aHuman Physiology. 615 24$aCell Biology. 615 24$aCell Physiology. 615 24$aAnimal Biochemistry. 615 7$aMalalties 676 $a574.874 702 $aImanaka$b Tsuneo$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aShimozawa$b Nobuyuki$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910373904003321 996 $aPeroxisomes: Biogenesis, Function, and Role in Human Disease$92034062 997 $aUNINA