LEADER 03594nam 2200937z- 450 001 9910372785703321 005 20231214133541.0 010 $a3-03928-091-0 035 $a(CKB)4100000010163769 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/48415 035 $a(EXLCZ)994100000010163769 100 $a20202102d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGenome Mining and Marine Microbial Natural Products 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 electronic resource (202 p.) 311 $a3-03928-090-2 330 $aTwo review papers, eight research articles, and one brief report were published in this Special Issue. They showed the rich resources that are present within the genomes of marine microorganisms and discussed the use of recently developed tools and technologies to exploit this genetic richness. Examples include the rational supply of precursors according to the relevant biosynthetic pathway and stress driven discovery together with the use of histone deacetylase inhibitors to facilitate the discovery of new bioactive molecules with potential biopharmaceutical applications. We believe that the content of this Special Issue reflects the current state-of-the-art research in this area and highlights the interesting strategies that are being employed to uncover increasing numbers of exciting novel compounds for drug discovery from marine genetic resources. 610 $aantibacterial activity 610 $apolyketide synthase 610 $ahalo-extremophyles 610 $aantibacterial 610 $agene cluster 610 $aPenicillium chrysogenum 610 $abacillomycin 610 $asecondary metabolites 610 $adrug discovery 610 $abiosynthesis 610 $apolycyclic tetramate macrolactams 610 $aactinobacteria 610 $abiosynthetic gene clusters 610 $aphylotype 610 $acomparative genomics 610 $aIclR family regulator 610 $apolyketide antibiotics 610 $aantifungal 610 $afatty acid amide 610 $aAntarctica 610 $amarine microorganisms 610 $aNdgRyo 610 $anonribosomal peptides 610 $aMarisediminicola 610 $agenome mining 610 $aantimicrobial 610 $asponge 610 $aStachybotrys 610 $acarotenoid 610 $amarine 610 $aarchaea 610 $ahaloenzymes 610 $anatural products 610 $aStreptomyces sp. SCSIO 40010 610 $a16S rRNA metagenomics 610 $aecotype 610 $amedicinal chemistry 610 $acytotoxicity 610 $amarine natural products (MNPs) 610 $aStreptomyces 610 $amarine Bacillus 610 $aantimicrobial activity 610 $aamino compound 610 $abacillibactin 610 $ameroterpenoid 610 $afibrinolytic activity 610 $ametal stress technique 610 $aisoindolinone biosynthesis 610 $aStreptomyces pratensis 610 $ahistone-deacetylase inhibitor 610 $amarine natural product 610 $aOdiel marshlands 700 $aHong$b Kui$4auth$01301183 702 $aZhang$b Changsheng$4auth 702 $aDobson$b Alan$4auth 906 $aBOOK 912 $a9910372785703321 996 $aGenome Mining and Marine Microbial Natural Products$93025772 997 $aUNINA