LEADER 03697nam 2200973z- 450 001 9910372785703321 005 20210211 010 $a3-03928-091-0 035 $a(CKB)4100000010163769 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/48415 035 $a(oapen)doab48415 035 $a(EXLCZ)994100000010163769 100 $a20202102d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aGenome Mining and Marine Microbial Natural Products 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (202 p.) 311 08$a3-03928-090-2 330 $aTwo review papers, eight research articles, and one brief report were published in this Special Issue. They showed the rich resources that are present within the genomes of marine microorganisms and discussed the use of recently developed tools and technologies to exploit this genetic richness. Examples include the rational supply of precursors according to the relevant biosynthetic pathway and stress driven discovery together with the use of histone deacetylase inhibitors to facilitate the discovery of new bioactive molecules with potential biopharmaceutical applications. We believe that the content of this Special Issue reflects the current state-of-the-art research in this area and highlights the interesting strategies that are being employed to uncover increasing numbers of exciting novel compounds for drug discovery from marine genetic resources. 606 $aBiology, life sciences$2bicssc 610 $a16S rRNA metagenomics 610 $aactinobacteria 610 $aamino compound 610 $aAntarctica 610 $aantibacterial 610 $aantibacterial activity 610 $aantifungal 610 $aantimicrobial 610 $aantimicrobial activity 610 $aarchaea 610 $abacillibactin 610 $abacillomycin 610 $abiosynthesis 610 $abiosynthetic gene clusters 610 $acarotenoid 610 $acomparative genomics 610 $acytotoxicity 610 $adrug discovery 610 $aecotype 610 $afatty acid amide 610 $afibrinolytic activity 610 $agene cluster 610 $agenome mining 610 $ahalo-extremophyles 610 $ahaloenzymes 610 $ahistone-deacetylase inhibitor 610 $aIclR family regulator 610 $aisoindolinone biosynthesis 610 $amarine 610 $amarine Bacillus 610 $amarine microorganisms 610 $amarine natural product 610 $amarine natural products (MNPs) 610 $aMarisediminicola 610 $amedicinal chemistry 610 $ameroterpenoid 610 $ametal stress technique 610 $anatural products 610 $aNdgRyo 610 $anonribosomal peptides 610 $aOdiel marshlands 610 $aPenicillium chrysogenum 610 $aphylotype 610 $apolycyclic tetramate macrolactams 610 $apolyketide antibiotics 610 $apolyketide synthase 610 $asecondary metabolites 610 $asponge 610 $aStachybotrys 610 $aStreptomyces 610 $aStreptomyces pratensis 610 $aStreptomyces sp. SCSIO 40010 615 7$aBiology, life sciences 700 $aHong$b Kui$4auth$01301183 702 $aZhang$b Changsheng$4auth 702 $aDobson$b Alan$4auth 906 $aBOOK 912 $a9910372785703321 996 $aGenome Mining and Marine Microbial Natural Products$93025772 997 $aUNINA