LEADER 05894nam 2201165z- 450 001 9910372783603321 005 20231214133443.0 010 $a3-03928-075-9 035 $a(CKB)4100000010163790 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42861 035 $a(EXLCZ)994100000010163790 100 $a20202102d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCell-Free Nucleic Acids 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 electronic resource (248 p.) 311 $a3-03928-074-0 330 $aThe deficits of mammography and the potential of noninvasive diagnostic testing using circulating miRNA profiles are presented in our first review article. Exosomes are important in the transfer of genetic information. The current knowledge on exosome-associated DNAs and on vesicle-associated DNAs and their role in pregnancy-related complications is presented in the next article. The major obstacle is the lack of a standardized technique for the isolation and measurement of exosomes. One review has summarized the latest results on cell-free nucleic acids in inflammatory bowel disease (IBD). Despite the extensive research, the etiology and exact pathogenesis are still unclear, although similarity to the cell-free ribonucleic acids (cfRNAs) observed in other autoimmune diseases seems to be relevant in IBD. Liquid biopsy is a useful tool for the differentiation of leiomyomas and sarcomas in the corpus uteri. One manuscript has collected the most important knowledge of mesenchymal uterine tumors and shows the benefits of noninvasive sampling. Microchimerism has also recently become a hot topic. It is discussed in the context of various forms of transplantation and transplantation-related advanced therapies, the available cell-free nucleic acid (cfNA) markers, and the detection platforms that have been introduced. Ovarian cancer is one of the leading serious malignancies among women, with a high incidence of mortality; the introduction of new noninvasive diagnostic markers could help in its early detection and treatment monitoring. Epigenetic regulation is very important during the development of diseases and drug resistance. Methylation changes are important signs during ovarian cancer development, and it seems that the CDH1 gene is a potential candidate for being a noninvasive biomarker in the diagnosis of ovarian cancer. Preeclampsia is a mysterious disease?despite intensive research, the exact details of its development are unknown. It seems that cell-free nucleic acids could serve as biomarkers for the early detection of this disease. Three research papers deal with the prenatal application of cfDNA. Copy number variants (CNVs) are important subjects for the study of human genome variations, as CNVs can contribute to population diversity and human genetic diseases. These are useful in NIPT as a source of population specific data. The reliability of NIPT depends on the accurate estimation of fetal fraction. Improvement in the success rate of in vitro fertilization (IVF) and embryo transfer (ET) is an important goal. The measurement of embryo-specific small noncoding RNAs in culture media could improve the efficiency of ET. 610 $ascreening 610 $asingle nucleotide polymorphism 610 $apredictive and preventive approach 610 $aPTEN 610 $acell-free DNAs 610 $afetal fraction 610 $agestational hypertension 610 $aRASSF1 610 $aCDH1 610 $aRT-PCR 610 $acfDNA 610 $astatistical models 610 $ahematopoietic stem cell transplantation 610 $aNanoString 610 $asolid organ transplantation 610 $acopy number variants 610 $asarcomas 610 $aliquid biopsy 610 $aobesity 610 $afetal DNA 610 $aneutrophil extracellular traps 610 $amammography 610 $anon-invasive prenatal testing 610 $aovarian cancer 610 $acirculating miRNA 610 $apyrosequencing 610 $agrowth retardation 610 $apreeclampsia 610 $agestational diabetes mellitus 610 $abiomarker 610 $ainflammatory bowel disease 610 $amulti-level diagnostics 610 $aPAX1 610 $apopulation study 610 $anuclease activity 610 $aNETosis 610 $aomics 610 $apiRNA 610 $acell-free DNA 610 $aprediction 610 $aleiomyosarcomas 610 $anetwork analysis 610 $aNGS 610 $astatistical methods 610 $acirculating nucleic acids 610 $adeletion/insertion polymorphism 610 $agender differences 610 $aleiomyomas 610 $afetal growth restriction 610 $ablood plasma 610 $aexosomes 610 $amiRNA 610 $apregnancy-related complications 610 $aNIPT 610 $agenetic marker 610 $acell-free nucleic acids 610 $aextracellular vesicles 610 $aexpression 610 $anext generation sequencing 610 $abreast cancer 610 $aindividualized patient profile 610 $acirculating tumor cells 610 $amaternal serum screening 610 $apersonalized medicine 610 $aembryo culture medium 610 $aC19MC microRNA 610 $aDNA 610 $acell-free RNAs 610 $az-score 610 $afetal cells 610 $amicrochimerism 610 $aaging 610 $aplasma 700 $aNagy$b Ba?lint$4auth$01290164 906 $aBOOK 912 $a9910372783603321 996 $aCell-Free Nucleic Acids$93021375 997 $aUNINA