LEADER 04777nam 22005055 450 001 9910369937903321 005 20200701181204.0 010 $a3-030-20812-5 024 7 $a10.1007/978-3-030-20812-7 035 $a(CKB)4100000009152810 035 $a(MiAaPQ)EBC5888536 035 $a(DE-He213)978-3-030-20812-7 035 $a(PPN)269145117 035 $a(EXLCZ)994100000009152810 100 $a20190829d2020 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDifficult To Treat Asthma $eClinical Essentials /$fedited by Sandhya Khurana, Fernando Holguin 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Humana,$d2020. 215 $a1 online resource (339 pages) 225 1 $aRespiratory Medicine,$x2197-7372 311 $a3-030-20811-7 327 $aScope of the problem, definition and pathophysiology -- Is it Asthma? Recognizing asthma mimics -- Beyond Refills: Promoting Adherence to Optimize Outcomes -- Addressing Comorbidities in Difficult Asthma -- Evaluation and Management of Work-Related Asthma -- Advances in Inhaled Medications -- Heterogeneity in Severe asthma -- Biomarkers, Targeted Therapies, Biologics and Bronchial Thermoplasty -- Practical Considerations in Management of Allergic Asthma -- Practical considerations in the management of eosinophilic asthma -- Practical considerations in management of non-eosinophilic asthma -- Practical considerations in management of obesity associated asthma -- Severe asthma in pregnancy: Special considerations -- Severe asthma in childhood: Special considerations -- High-risk asthma clinic: Putting it all together -- Difficult Asthma: Unmet Needs and Future Directions. . 330 $aThis book provides a practical, stepwise, evidence-based approach to effective management of patients with difficult to treat asthma. The impact of asthma on morbidity and healthcare utilization increases exponentially with severity. Severe refractory asthma accounts for less than 5% of all asthma. Its prevalence, however, is often overestimated as there are several other confounding factors that make asthma ?difficult to treat?. Many novel (albeit expensive) therapies are now available and providers caring for patients with severe asthma are charged with selecting the best evidence treatment. This calls for complex and nuanced decision-making. Whether people with asthma gain and maintain control over their condition depends not only on the availability of effective drugs, but also multiple patient and healthcare provider behaviors. Therefore, now more than ever, it has become increasingly important to differentiate ?difficult? from ?severe refractory? asthma to allow identification of patients most likely to benefit from these therapies. This volume delves into the current understanding of mechanisms and increasingly recognized heterogeneity of this complex disease. It discusses a structured approach to identification and optimization of factors contributing to poor asthma control, including nonadherence, comorbidities and occupational/environmental triggers. The book includes ?state of the art? reviews on recent advances in traditional and targeted asthma therapies, as well as a glimpse into what the future may hold. Highlights include a comprehensive guide to management of severe asthma in children and pregnancy, as well as practical considerations to management of asthma based on different clinical phenotypes. Each chapter is authored by leading experts in the field who share their own clinical approach. This is an ideal guide for clinical pulmonologists and allergist/immunologists, as well as primary care providers, physician extenders in specialty practice, physicians in pulmonary/allergy training, and even industry partners. . 410 0$aRespiratory Medicine,$x2197-7372 606 $aRespiratory organs?Diseases 606 $aPrimary care (Medicine) 606 $aPneumology/Respiratory System$3https://scigraph.springernature.com/ontologies/product-market-codes/H33134 606 $aPrimary Care Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H51000 615 0$aRespiratory organs?Diseases. 615 0$aPrimary care (Medicine). 615 14$aPneumology/Respiratory System. 615 24$aPrimary Care Medicine. 676 $a616.238 676 $a616.23806 702 $aKhurana$b Sandhya$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aHolguin$b Fernando$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910369937903321 996 $aDifficult To Treat Asthma$92266471 997 $aUNINA