LEADER 04863nam 22006735 450 001 9910369935303321 005 20200703054027.0 010 $a3-030-23417-7 024 7 $a10.1007/978-3-030-23417-1 035 $a(CKB)4100000009758981 035 $a(DE-He213)978-3-030-23417-1 035 $a(MiAaPQ)EBC5972835 035 $a(PPN)24282577X 035 $a(EXLCZ)994100000009758981 100 $a20191105d2020 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCentral Nervous System Metastases /$fedited by Manmeet Ahluwalia, Philippe Metellus, Riccardo Soffietti 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (XIII, 421 p. 45 illus., 37 illus. in color.) 311 $a3-030-23416-9 327 $aPREFACE -- I Epidemiology -- II Pathology and Biology -- 1 Pathology of brain metastases -- 2 Translationnal approaches -- 3 Molecular mechanisms driving brain metastases development -- 4 Genomics characterization of BM -- 5 BM cell partners and tumor microenvironment -- 6 Experimental models of Brain Metastases -- III Clinical presentation and symptom management -- 7 Clinical presentation -- 8 Epilepsy in CNS metastases -- 9 Safety, tolerability and use of steroids in CNS metastasis patients -- 10 Thrombo-embolic complications in BM patients -- IV Imaging -- 11 BM diagnosis and monitoring -- 12 Metabolic imaging of BM -- 13 Radiation necrosis and progression assessment and definition -- V Surgery -- 14 Modern surgical techniques -- 15 Quality of surgical resection assessment -- 16 Indications and emerging concepts in the era molecular biology -- VI Radiation Therapy -- 17 Stereotatic radiosurgery -- 18 WBRT -- 19 Combined radiation therapy and systemic treatment -- VII Systemic treatment -- 20 Lung -- 21 Breast.-. 22 Melanoma -- 23 Miscellaneous -- VIII Neurocognition and QoL -- IV Leptomeningeal disease -- X Prevention/Prohylaxis strategies -- XI Prognosis and prognostic models -- XII Clinical trials / Endpoints and outcome assessment. . 330 $aThis book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors. 606 $aNeurosurgery 606 $aRadiotherapy 606 $aOncology   606 $aCancer research 606 $aQuality of life 606 $aNeurosurgery$3https://scigraph.springernature.com/ontologies/product-market-codes/H39000 606 $aRadiotherapy$3https://scigraph.springernature.com/ontologies/product-market-codes/H29056 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aQuality of Life Research$3https://scigraph.springernature.com/ontologies/product-market-codes/X23000 615 0$aNeurosurgery. 615 0$aRadiotherapy. 615 0$aOncology  . 615 0$aCancer research. 615 0$aQuality of life. 615 14$aNeurosurgery. 615 24$aRadiotherapy. 615 24$aOncology. 615 24$aCancer Research. 615 24$aQuality of Life Research. 676 $a617.48 676 $a616.9948 702 $aAhluwalia$b Manmeet$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMetellus$b Philippe$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSoffietti$b Riccardo$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910369935303321 996 $aCentral Nervous System Metastases$92083300 997 $aUNINA