LEADER 01048nam0 22002771i 450 001 SUN0021276 005 20161012084825.503 010 $a35-406-5790-8$d0.00 100 $a20040804d2000 |0engc50 ba 101 $aeng 102 $aGB 105 $a|||| ||||| 200 1 $a*Principles of sedimentary basin analysis$fAndrew D. Miall 205 $a3. ed 210 $aBerlin$cSpringer$d2000 215 $axxi, 616 p.$cill.$d28 cm. 620 $dBerlin$3SUNL000066 676 $a552.5$cSedimentologia. Rocce sedimentarie$v22 700 1$aMiall$b, Andrew D.$3SUNV017345$0448213 712 $aSpringer$3SUNV000178$4650 790 1$aMiall, A. D.$zMiall, Andrew D.$3SUNV102028 801 $aIT$bSOL$c20200921$gRICA 912 $aSUN0021276 950 $aUFFICIO DI BIBLIOTECA DEL DIPARTIMENTO DI SCIENZE E TECNOLOGIE AMBIENTALI BIOLOGICHE E FARMACEUTICHE$d17CONS Sh13 $e17FSA1369 20040804 $sBuono 996 $aPrinciples of sedimentary basin analysis$9108656 997 $aUNICAMPANIA LEADER 05142nam 22012853a 450 001 9910367757003321 005 20250203235429.0 010 $a9783039211531 010 $a3039211536 024 8 $a10.3390/books978-3-03921-153-1 035 $a(CKB)4100000010106147 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/56626 035 $a(ScCtBLL)95f615b6-8862-45fa-a25e-11c9a21fe073 035 $a(OCoLC)1163835999 035 $a(EXLCZ)994100000010106147 100 $a20250203i20192019 uu 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPolyamine Metabolism in Disease and Polyamine-Targeted Therapies$fTracy Murray-Stewart 210 1$aBasel, Switzerland :$cMDPI,$d2019. 215 $a1 electronic resource (240 p.) 311 08$a9783039211524 311 08$a3039211528 330 $aSpermine, spermidine, and putrescine constitute the mammalian polyamines, abundant polycations with essential roles in critical cell functions. As such, intracellular polyamine concentrations are tightly regulated through biosynthesis, catabolism, and transport. The multifaceted effects of polyamine dysregulation have contributed to its role in multiple disease processes but have also implicated it as target for preventive or therapeutic intervention. The correlation between oncogene-mediated elevation of polyamine biosynthesis and cancer is well established, and induced polyamine catabolism contributes to carcinogenesis that is associated with certain forms of chronic infection and/or inflammation. In addition to cancer, polyamines are involved in the pathologies of neurodegenerative diseases, parasitic and infectious diseases, wound healing, ischemia/reperfusion injuries, and certain age-related conditions, as polyamines concentrations are reported to decrease with age. As in cancer, polyamine-based therapies for these conditions are an area of active investigation. With recent advances in immunotherapy, interest has increased regarding polyamine-associated modulation of immune responses as well as potential immunoregulation of polyamine metabolism, the results of which could have relevance to multiple disease processes. The goal of this Special Issue of Medical Sciences is to present the most recent advances in polyamine research as it relates to health, disease, and/or therapy. 610 $aprotein synthesis in cancer 610 $aneuroblastoma 610 $aepigenetics 610 $aDrosophila imaginal discs 610 $apneumococcal pneumonia 610 $atransgenic mice 610 $aspermidine/spermine N1-acetyl transferase 610 $a?-difluoromethylornithine 610 $aMYC 610 $askeletal muscle 610 $aprotein expression 610 $acurcumin 610 $acolorectal cancer 610 $aautophagy 610 $ahuman embryonic kidney 293 (HEK293) 610 $amelanoma 610 $atumor immunity 610 $aSnyder-Robinson Syndrome 610 $aStreptococcus pneumoniae 610 $aB-lymphocytes 610 $aautoimmunity 610 $aspermine oxidase 610 $acell differentiation 610 $adiferuloylmethane 610 $aimmunity 610 $aantizyme 610 $atransgenic mouse 610 $apolyamine 610 $ahirsutism 610 $achemoprevention 610 $aCRISPR 610 $atransglutaminase 610 $apolyamine analogs 610 $aNF-?B 610 $aspermine synthase 610 $aatrophy 610 $aaging 610 $aoxidative stress 610 $amast cells 610 $aAfrican sleeping sickness 610 $apancreatic ductal adenocarcinoma 610 $aeflornithine 610 $acarcinogenesis 610 $aornithine decarboxylase 610 $apolyamine transport inhibitor 610 $aputrescine 610 $aneutrophils 610 $aspermidine 610 $auntranslated region 610 $aspermine 610 $apolyphenol 610 $aM2 macrophages 610 $apolyamine transport system 610 $ametabolism 610 $adifluoromethylorthinine 610 $aDFMO 610 $aantizyme inhibitors 610 $acapsule 610 $apolyamine transport 610 $aeosinophils 610 $aMCF-7 cells 610 $adifluoromethylornithine 610 $apolyamine metabolism 610 $amutant BRAF 610 $apolyamines 610 $acadaverine 610 $aproteomics 610 $aairway smooth muscle cells 610 $abreast cancer 610 $aX-linked intellectual disability 610 $acomplementation 610 $aT-lymphocytes 610 $abis(ethyl)polyamine analogs 610 $aantizyme 1 610 $acancer 610 $aosteosarcoma 700 $aMurray-Stewart$b Tracy$01309855 801 0$bScCtBLL 801 1$bScCtBLL 906 $aBOOK 912 $a9910367757003321 996 $aPolyamine Metabolism in Disease and Polyamine-Targeted Therapies$93029658 997 $aUNINA