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010   $a3-03921-328-8
035   $a(CKB)4100000010106154
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53609
035   $a(EXLCZ)994100000010106154
100   $a20202102d2019      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aMitochondrial Dysfunction in Aging and Diseases of Aging
210   $cMDPI - Multidisciplinary Digital Publishing Institute$d2019
215   $a1 electronic resource (270 p.)
311   $a3-03921-327-X 
330   $aThis collection of review articles authored by international experts pulls together current information about the role of mitochondria in aging and diseases of aging. Mitochondria are vitally important cellular organelles and undergo their own aging process becoming less efficient in aged animals including humans. These changes have wide-ranging significance contributing to immune dysfunction (autoimmunity and immune deficiency), inflammation, delayed healing, skin and retinal damage, cancer and most of the degenerative diseases of aging. Mitochondrial aging predisposes to drug toxicity in the geriatric population and to many of the features of normal aging. The research detailed in this book summarizes current understanding of the role of mitochondria in the complex molecular changes of aging, moving on to specific diseases of aging. Mitochondrial dysfunction is an important target for development of treatments for aging and disease. The last article details how exercise is a treatment and combats many features of the aging process.
610   $aage-related diseases
610   $asphingolipids
610   $aglaucoma
610   $aALS
610   $aneurodegeneration
610   $amitochondrial dysfunction
610   $aadaptive immunity
610   $asenescence
610   $ade-emergence
610   $ainnate immunity
610   $acell danger response
610   $amitochondrial transfer
610   $aaxonal transport
610   $acytokines
610   $amitochondrial
610   $aage-related macular degeneration
610   $aprevention
610   $aheart failure
610   $apurinergic signaling
610   $aautophagy
610   $aAlzheimer's disease
610   $adiabetic retinopathy
610   $aproteostasis
610   $a1
610   $aimmunosenescence
610   $aMiro1
610   $aROS
610   $ametabolism
610   $aoptic nerve
610   $apolypharmacy
610   $aeIF2?
610   $aParkin
610   $acoenzyme Q10
610   $aneurodegenerative disease
610   $aDNA damage
610   $askin
610   $aexercise
610   $anucleotide metabolism
610   $apasteur effect
610   $astress response
610   $ainflammation
610   $aretina
610   $adrug-induced mitochondrial toxicity
610   $aneuroinflammation
610   $aexosomes
610   $areactive oxygen species
610   $a25(OH)D
610   $acardiomyopathy
610   $acrabtree effect
610   $ainsulin resistance
610   $acardiovascular disease
610   $aageing
610   $agenetic mutations
610   $ametabokines
610   $amitochondria
610   $amultiple sclerosis
610   $aaerobic
610   $ahealing cycle
610   $aSOD1
610   $amitophagy
610   $aPINK1
610   $atype 2 diabetes
610   $aintegrated cell stress response
610   $amorbidity and mortality
610   $aultraviolet
610   $aphotoageing
610   $acancer
610   $aaging
610   $a25(OH)2D
610   $alysosome
610   $aNAD+
610   $aParkinson's disease
700   $aHaas$b Richard H$4auth$038094
906   $aBOOK
912   $a9910367756303321
996   $aMitochondrial Dysfunction in Aging and Diseases of Aging$93040673
997   $aUNINA