LEADER 05309nam 2201237z- 450 001 9910367753703321 005 20231214133535.0 010 $a3-03921-450-0 035 $a(CKB)4100000010106180 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/44401 035 $a(EXLCZ)994100000010106180 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCurcumin in Health and Disease 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 electronic resource (274 p.) 311 $a3-03921-449-7 330 $aThe plant-derived polyphenol curcumin has been used in promoting health and combating disease for thousands of years. Its therapeutic effects have been successfully utilized in Ayurvedic and Traditional Chinese Medicine in order to treat inflammatory diseases. Current results from modern biomolecular research reveal the modulatory effects of curcumin on a variety of signal transduction pathways associated with inflammation and cancer. In this context, curcumin?s antioxidant, anti-inflammatory, anti-tumorigenic, and even anti-metastatic activities are discussed. On the cellular level, the reduced activity of several transcription factors (such as NFkB or AP-1) and the suppression of inflammatory cytokines, matrix degrading enzymes, metastasis related genes and even microRNAs are reported. On functional levels, these molecular effects translate into reduced proliferative, invasive, and metastatic capacity, as well as induced tumor cell apoptosis. All these effects have been observed not only in vitro but also in animal models. In combination with anti-neoplastic drugs like Taxol, kinase inhibitors, and radiation therapy, curcumin potentiates the drugs? therapeutic power and can protect against undesired side effects. Natural plant-derived compounds like curcumin have one significant advantage: They do not usually cause side effects. This feature qualifies curcumin for primary prevention in healthy persons with a predisposition to cancer, arteriosclerosis, or chronic inflammatory diseases. Nonetheless, curcumin is considered safe, although potential toxic effects stemming from high dosages, long-term intake, and pharmacological interactions with other compounds have yet to be assessed. This Special Issue examines in detail and updates current research on the molecular targets, protective effects, and modes of action of natural plant-derived compounds and their roles in the prevention and treatment of human diseases. 610 $aminerals 610 $acancer treatment 610 $achitosan 610 $aneurodegeneration 610 $aantioxidant activity 610 $asenescence 610 $atumor proliferation 610 $ananoparticles 610 $aantimicrobial agents 610 $aoxidative metabolites 610 $adrug discovery 610 $aAkt/mTOR signaling 610 $amicronutrients 610 $aulcerative colitis 610 $atransmission electron microscopy 610 $ametabolic reprogramming 610 $acurcumin 610 $adeath receptor 610 $achaperone-mediated autophagy 610 $awound healing 610 $abrain ischemia 610 $aautophagy 610 $aAlzheimer's disease 610 $agenes 610 $atransthyretin 610 $ainflammatory bowel disease 610 $acellular pathway 610 $acentrifugal partition chromatography 610 $anutrition 610 $aamyloid 610 $aCurcuma longa 610 $aprotein aggregation 610 $asupportive care 610 $aIL-17 610 $asenolytics 610 $acomplementary medicine 610 $amacronutrients 610 $astructure activity relationship 610 $agastroprotection 610 $aZingiberaceae 610 $aanti-inflamation 610 $aTLC bioautography 610 $amicrobiota 610 $aglioblastoma multiforme 610 $aamyloidosis 610 $aSHMT2 610 $aantioxidants 610 $asilica 610 $aapoptosis 610 $areflux esophagitis 610 $agastric ulcer 610 $aTLC-MS 610 $aanti-cancer 610 $aanticancer 610 $aImageJ 610 $aanti-tumor 610 $adelivery system 610 $awound 610 $aHelicobacter pylori 610 $adirect protein binding 610 $aprotein misfolding 610 $atumor growth 610 $adiet 610 $aCrohn's disease 610 $ahydrostatic counter-current chromatography 610 $aageing 610 $arenal cell cancer 610 $agastric cancer 610 $aamino-acids 610 $aSTAT3 610 $amechanism of action 610 $ainflamm-aging 610 $amitophagy 610 $anecrotizing enterocolitis 610 $acell cycling 610 $avitamins 610 $aturmeric tuber 610 $acancer 610 $atau protein 700 $aBachmeier$b Beatrice$4auth$01287693 906 $aBOOK 912 $a9910367753703321 996 $aCurcumin in Health and Disease$93020305 997 $aUNINA