LEADER 03949nam 2201213z- 450 001 9910367750403321 005 20231214133409.0 010 $a3-03921-408-X 035 $a(CKB)4100000010106213 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53845 035 $a(EXLCZ)994100000010106213 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMolecular Mechanism of Alzheimer's Disease 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 electronic resource (228 p.) 311 $a3-03921-407-1 330 $aAlzheimer?s disease (AD) is an age-related neurological disease that affects tens of millions of people, in addition to their carers. Hallmark features of AD include plaques composed of amyloid beta, as well as neurofibrillary tangles of tau protein. However, despite more than a century of study, the cause of Alzheimer?s disease remains unresolved. The roles of amyloid beta and tau are being questioned and other causes of AD are now under consideration. The contributions of researchers, model organisms, and various hypotheses will be examined in this Special Issue. 610 $aHOTAIR 610 $aneurosciences 610 $asleep disturbance 610 $apositron emission tomography (PET) 610 $avitamin B complex 610 $aneurodegeneration 610 $aTau 610 $amiR-15/107 610 $adefault-mode network 610 $acomplement receptor 1 610 $aneuronal differentiation 610 $aepigenetics 610 $abrain glucose metabolism 610 $aoligomerization 610 $agenetic risk 610 $aA?O receptors 610 $aprion 610 $aryanodine receptor 610 $atype 3 diabetes 610 $acomplement 610 $acognitive behavioral therapy for insomnia 610 $acognitive function 610 $aepigenome-wide association study 610 $aAlzheimer?s disease 610 $acalcium signaling 610 $a?-secretase 610 $atau 610 $aProlyl isomerases 610 $aNEAT1 610 $acomplement C3b/C4b receptor 610 $aproteostasis 610 $aamyloid beta 610 $ayeast 610 $aslow-wave sleep 610 $aamyloid ? 610 $anutrition 610 $a4 610 $aprotein aggregation 610 $aapolipoprotein E 610 $adementia 610 $aMALAT1 610 $ainositol 1 610 $alncRNAs 610 $amolecular biology 610 $amethylenetetrahydrofolate reductase MTHFR gene 610 $a5-trisphosphate receptor 610 $aCR1 density 610 $amiR-34c 610 $aaggregation 610 $aheat shock protein 610 $adendritic spine 610 $aS-adenosylmethionine 610 $abeta amyloid 610 $aion channel 610 $ainflammation 610 $asleep fragmentation 610 $acystathionine-?-lyase CTH gene 610 $aDNA methylation 610 $aheat shock response 610 $amicroglia 610 $adrug target discovery 610 $aamyloid-? oligomer 610 $atherapy 610 $aCR1 length polymorphism 610 $amethylome 610 $aAPOE gene 610 $aubiquitin 610 $amagnetic resonance imaging (MRI) 610 $aneuronal degeneration 610 $atype 2 diabetes 610 $aPin1 610 $amild cognitive impairment 610 $adairy products 610 $aendoplasmic reticulum 610 $aoxidative stress 610 $aHispanics 610 $aCDK5R1 700 $aMacreadie$b Ian$4auth$01325223 906 $aBOOK 912 $a9910367750403321 996 $aMolecular Mechanism of Alzheimer's Disease$93036703 997 $aUNINA LEADER 07975nam 2202197z- 450 001 9910346684603321 005 20231214133405.0 010 $a3-03897-823-X 035 $a(CKB)4920000000094823 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/43974 035 $a(EXLCZ)994920000000094823 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aContemporary natural philosophy and philosophies$hPart 1 /$fspecial issue editors, Prof. Dr. Gordana Dodig-Crnkovic and Prof. Dr. Marcin J. Schroeder 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 electronic resource (350 p.) 311 $a3-03897-822-1 330 $aModern information communication technology eradicates barriers of geographic distances, making the world globally interdependent, but this spatial globalization has not eliminated cultural fragmentation. The Two Cultures of C.P. Snow (that of science?technology and that of humanities) are drifting apart even faster than before, and they themselves crumble into increasingly specialized domains. Disintegrated knowledge has become subservient to the competition in technological and economic race leading in the direction chosen not by the reason, intellect, and shared value-based judgement, but rather by the whims of autocratic leaders or fashion controlled by marketers for the purposes of political or economic dominance. If we want to restore the authority of our best available knowledge and democratic values in guiding humanity, first we have to reintegrate scattered domains of human knowledge and values and offer an evolving and diverse vision of common reality unified by sound methodology. This collection of articles responds to the call from the journal Philosophies to build a new, networked world of knowledge with domain specialists from different disciplines interacting and connecting with other knowledge-and-values-producing and knowledge-and-values-consuming communities in an inclusive, extended, contemporary natural?philosophic manner. In this process of synthesis, scientific and philosophical investigations enrich each other?with sciences informing philosophies about the best current knowledge of the world, both natural and human-made?while philosophies scrutinize the ontological, epistemological, and methodological foundations of sciences, providing scientists with questions and conceptual analyses. This is all directed at extending and deepening our existing comprehension of the world, including ourselves, both as humans and as societies, and humankind. 606 $aScience$xPhilosophy 606 $aPhilosophy of nature 610 $apessimistic induction 610 $aqualitative ontology 610 $adissipative structures 610 $aphysicalism 610 $aagent-based reasoning 610 $athermodynamics 610 $athe logic of nature 610 $areverse mathematics 610 $atheoretical unity 610 $astate-space approach 610 $acommon good 610 $anaturalization of logic 610 $amonad 610 $ametaphysics 610 $areflexive psychology 610 $aknowledge 610 $aneurodynamics 610 $aconsciousness 610 $athird-way reasoning 610 $ainduction and discovery of laws 610 $amind-matter relations 610 $aexoplanet 610 $aSecond Law of thermodynamics 610 $aunitarity 610 $aphilosophical foundations 610 $ain the name of nature 610 $abig crunch 610 $aepistemology 610 $aeco-cognitive model 610 $aactive imagination 610 $aaesthetics in science 610 $ascience 610 $asecond-person description 610 $asubsumptive hierarchy 610 $a1st-person and 3rd-person perspectives 610 $adiscursive space 610 $aspace flight 610 $acomplexity 610 $acybernetics 610 $acosmology 610 $amatter 610 $arealism 610 $aeco-cognitive openness 610 $ahylomorphism 610 $ameasurement 610 $afallacies 610 $ainduction 610 $avacuum 610 $aphysics 610 $amental representation 610 $aembodiment 610 $aproblem of induction 610 $acontradiction 610 $ainternalism 610 $aJungian psychology 610 $asynthesis 610 $aexceptional experiences 610 $amind 610 $arelational biology 610 $asymmetry breaking 610 $aemergence 610 $aphenomenological psychology 610 $aAristotle's four causes 610 $ahumanistic management 610 $areal computing 610 $aA.N. 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Schelling 610 $aL. Smolin 610 $aR.M. Unger 610 $aAristotle 610 $adual aspects 610 $aprocess 610 $atheory of everything 610 $aphilosophy of science 610 $acognition 610 $acompositional hierarchy 610 $aautocatalysis 610 $adiscourse 610 $aemergentist reductionism 610 $aform 610 $aregulation 610 $acontingency 610 $aendogenous selection 610 $acategory theory 615 0$aScience$xPhilosophy. 615 0$aPhilosophy of nature. 676 $a501 702 $aDodig Crnkovic$b Gordana$f1955- 702 $aSchroeder$b Marcin J. 906 $aBOOK 912 $a9910346684603321 996 $aContemporary natural philosophy and philosophies$93399392 997 $aUNINA