LEADER 04361nam 22013453a 450 001 9910367750403321 005 20250203235427.0 010 $a9783039214082 010 $a303921408X 024 8 $a10.3390/books978-3-03921-408-2 035 $a(CKB)4100000010106213 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53845 035 $a(ScCtBLL)db69e1af-5782-4846-81f7-14c2b9141c10 035 $a(OCoLC)1163824875 035 $a(oapen)doab53845 035 $a(EXLCZ)994100000010106213 100 $a20250203i20192019 uu 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMolecular Mechanism of Alzheimer's Disease$fIan Macreadie 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 210 1$aBasel, Switzerland :$cMDPI,$d2019. 215 $a1 electronic resource (228 p.) 311 08$a9783039214075 311 08$a3039214071 330 $aAlzheimer's disease (AD) is an age-related neurological disease that affects tens of millions of people, in addition to their carers. Hallmark features of AD include plaques composed of amyloid beta, as well as neurofibrillary tangles of tau protein. However, despite more than a century of study, the cause of Alzheimer's disease remains unresolved. The roles of amyloid beta and tau are being questioned and other causes of AD are now under consideration. The contributions of researchers, model organisms, and various hypotheses will be examined in this Special Issue. 606 $aBiology, life sciences$2bicssc 610 $aHOTAIR 610 $aneurosciences 610 $asleep disturbance 610 $apositron emission tomography (PET) 610 $avitamin B complex 610 $aneurodegeneration 610 $aTau 610 $amiR-15/107 610 $adefault-mode network 610 $acomplement receptor 1 610 $aneuronal differentiation 610 $aepigenetics 610 $abrain glucose metabolism 610 $aoligomerization 610 $agenetic risk 610 $aA?O receptors 610 $aprion 610 $aryanodine receptor 610 $atype 3 diabetes 610 $acomplement 610 $acognitive behavioral therapy for insomnia 610 $acognitive function 610 $aepigenome-wide association study 610 $aAlzheimer?s disease 610 $acalcium signaling 610 $a?-secretase 610 $atau 610 $aProlyl isomerases 610 $aNEAT1 610 $acomplement C3b/C4b receptor 610 $aproteostasis 610 $aamyloid beta 610 $ayeast 610 $aslow-wave sleep 610 $aamyloid ? 610 $anutrition 610 $a4 610 $aprotein aggregation 610 $aapolipoprotein E 610 $adementia 610 $aMALAT1 610 $ainositol 1 610 $alncRNAs 610 $amolecular biology 610 $amethylenetetrahydrofolate reductase MTHFR gene 610 $a5-trisphosphate receptor 610 $aCR1 density 610 $amiR-34c 610 $aaggregation 610 $aheat shock protein 610 $adendritic spine 610 $aS-adenosylmethionine 610 $abeta amyloid 610 $aion channel 610 $ainflammation 610 $asleep fragmentation 610 $acystathionine-?-lyase CTH gene 610 $aDNA methylation 610 $aheat shock response 610 $amicroglia 610 $adrug target discovery 610 $aamyloid-? oligomer 610 $atherapy 610 $aCR1 length polymorphism 610 $amethylome 610 $aAPOE gene 610 $aubiquitin 610 $amagnetic resonance imaging (MRI) 610 $aneuronal degeneration 610 $atype 2 diabetes 610 $aPin1 610 $amild cognitive impairment 610 $adairy products 610 $aendoplasmic reticulum 610 $aoxidative stress 610 $aHispanics 610 $aCDK5R1 615 7$aBiology, life sciences 700 $aMacreadie$b Ian$01325223 801 0$bScCtBLL 801 1$bScCtBLL 906 $aBOOK 912 $a9910367750403321 996 $aMolecular Mechanism of Alzheimer's Disease$93036703 997 $aUNINA LEADER 03542nam 2201009z- 450 001 9910576875603321 005 20220621 035 $a(CKB)5720000000008419 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/84519 035 $a(oapen)doab84519 035 $a(EXLCZ)995720000000008419 100 $a20202206d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAdvances on Smart Cities and Smart Buildings 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (226 p.) 311 08$a3-0365-4015-6 311 08$a3-0365-4016-4 330 $aModern cities are facing the challenge of combining competitiveness at the global city scale and sustainable urban development to become smart cities. A smart city is a high-tech, intensive and advanced city that connects people, information, and city elements using new technologies in order to create a sustainable, greener city; competitive and innovative commerce; and an increased quality of life. This Special Issue collects the recent advancements in smart cities and covers different topics and aspects. 606 $aHistory of engineering and technology$2bicssc 606 $aTechnology: general issues$2bicssc 610 $a15 minutes city 610 $aARIMA 610 $abatches prediction 610 $abike delivery 610 $abike sharing system 610 $acargo bike 610 $acargo cycle 610 $acategory clustering 610 $achallenge living lab 610 $achallenge-based learning 610 $acyber privacy 610 $acyber security 610 $acycle logistics 610 $adigitization 610 $aDistrito Tec 610 $aelectric vehicle 610 $aelectric vehicle emulator 610 $aelectric vehicle supply equipment 610 $aenergy demand forecast 610 $aEREV key components 610 $aEuropean projects 610 $aexpansion areas 610 $aextended range electric vehicle 610 $afacial recognition 610 $agoods delivery 610 $agraph theory 610 $aheuristic approach 610 $ahybrid model 610 $ainternet of things (IoT) 610 $aitinerary planning 610 $alevel optimization 610 $aMonterrey Metropolitan Zone (MMZ) 610 $an/a 610 $aopen innovation 610 $aoptimization methods 610 $apower theft 610 $asmart city 610 $asmart grid 610 $asmart meters 610 $asmart networks 610 $asmart sensors 610 $asmart tourism 610 $asmart transit 610 $asmart water/energy/mobility 610 $asmarter communities 610 $atechnologies 610 $atime series analysis 610 $aurban accessibility 610 $aUrban Basic Geostatistical Areas (AGEBs) 610 $aUrMoAC 610 $avehicle-to-building 610 $avehicle-to-grid 615 7$aHistory of engineering and technology 615 7$aTechnology: general issues 700 $aRoccotelli$b Michele$4edt$01322395 702 $aMangini$b Agostino Marcello$4edt 702 $aRoccotelli$b Michele$4oth 702 $aMangini$b Agostino Marcello$4oth 906 $aBOOK 912 $a9910576875603321 996 $aAdvances on Smart Cities and Smart Buildings$93034951 997 $aUNINA