LEADER 03747nam 2200769z- 450 001 9910367749603321 005 20231214133414.0 010 $a3-03921-679-1 035 $a(CKB)4100000010106221 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/48392 035 $a(EXLCZ)994100000010106221 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGenetic Determinants of Human Longevity 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 electronic resource (118 p.) 311 $a3-03921-678-3 330 $aIn the last two decades, due to the continuous increase of lifespans in Westernsocieties, and the consequent growing of the elderly population, have witnessedan increase in the number of studies on biological and molecular factors able topromote healthy aging and reach longevity. The study of the genetic componentof human longevity demonstrated that it accounts for 25% of intra populationphenotype variance. The efforts made to characterize the genetic determinantssuggested that the maintenance of cellular integrity, inflammation, oxidativestress response, DNA repair, as well as the use of nutrients, represent the mostimportant pathways correlated with a longer lifespan. However, although aplethora of variants were indicated to be associated with human longevity, onlyvery few were successfully replicated in different populations, probably becauseof population specificity, missing heritability as well as a complex interactionamong genetic factors with lifestyle and cultural factors, which modulate theindividual chance of living longer. Thus, many challenges remain to be addressedin the search for the genetic components of human longevity. This Special Issue isaimed to unify the progress in the analysis of the genetic determinants of humanlongevity, to take stock of the situation and point to future directions of the field.We invite submissions for reviews, research articles, short-communicationsdealing with genetic association studies in human longevity, including all types ofgenetic variation, as well as the characterization of longevity-related genes. 610 $aunknown zygosity 610 $aexceptional longevity 610 $aTERC 610 $axenobiotic-metabolizing enzymes 610 $alifespan 610 $agender-specific association 610 $along-livers 610 $apolymorphism 610 $acumulative incidence curves 610 $acardiovascular health 610 $atwins 610 $agenetic determinants of human longevity 610 $aTERT 610 $aSNP 610 $amoonlighting protein 610 $alongevity 610 $agenomics 610 $aAPOE 610 $apolygenic risk score 610 $asignal transduction 610 $axenobiotics 610 $asurvival 610 $aIPMK 610 $agenetic variation 610 $agenetic association study 610 $amolecular senescence 610 $azygosity 610 $alongevity-related genes 610 $aage-stratification 610 $alipid profile 610 $amortality 610 $aapolipoprotein E 610 $aaging 610 $amodel systems 610 $aleukocyte telomere length 610 $ainositol phosphates 610 $ahuman lifespan 610 $apopulations 700 $aRose$b Giuseppina$4auth$01288169 702 $aSørensen$b Mette$4auth 702 $aDato$b Serena$4auth 906 $aBOOK 912 $a9910367749603321 996 $aGenetic Determinants of Human Longevity$93020667 997 $aUNINA