LEADER 03541nam  2200661z- 450 
001 9910367744303321
005 20210211
010   $a3-03921-745-3
035   $a(CKB)4100000010106274
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42175
035   $a(oapen)doab42175
035   $a(EXLCZ)994100000010106274
100   $a20202102d2019      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aBioengineering Liver Transplantation
210   $cMDPI - Multidisciplinary Digital Publishing Institute$d2019
215   $a1 online resource (132 p.)
311 08$a3-03921-744-5 
330   $aThe aim of this Special Issue is to review, understand, and evaluate new and exciting opportunities from the field on regenerative medicine, biomaterials, and stem cell research for the bioengineering of human liver grafts that can be applied for transplantation and personalized treatment of end-stage liver disease.The development of culture conditions for long-term expansion of LGR5+ intestinal stem cells as crypt-villus structures demonstrated the feasibility of deriving complex, organ-like structures in vitro from primary adult tissues, including the liver. Moreover, human pluripotent stem cells (hPSCs) can be applied to generate functionally maturated liver and bile duct epithelial cells.In this Special Issue, we welcome reviews and original papers focussing on hepatic cell sources, including adult hepatic stem cells, organoids, fetal and induced pluripotent stem cells, and primary cells (i.e., hepatocytes, cholangiocytes, and endothelial cells) and how these cells can be applied in tissue engineering strategies to generate implantable and personalized liver grafts. Potential topics include, but are not limited to, the following: liver tissue engineering, liver regeneration, graft repair, liver stem cells and organoids, bio-scaffolds, and 3D printing.We invite you to contribute original research papers, as well as comprehensive reviews, aligned with these themes, to advance and improve the actual state-of-the-art in liver bioengineering and providing new opportunities for the imminent medical problem of organ and tissue shortage for transplantation.
606   $aBiology, life sciences$2bicssc
610   $a3D printing
610   $a3D structuring
610   $aadditive manufacturing
610   $abioengineered organ
610   $acopper toxicosis
610   $adirect printing
610   $aend-stage liver diseases
610   $ahepatobiliary stent
610   $ahydrogel
610   $aliver
610   $aliver bioreactors
610   $aliver regeneration
610   $aliver tissue bioengineering
610   $aliver transplantation
610   $amedical device
610   $an/a
610   $aoxygen persufflation
610   $apersonalized medicine
610   $apreclinical large animal model
610   $arandomized controlled trail
610   $areconditioning
610   $aregenerative medicine
610   $astem cell transplantation
610   $astem cells
610   $atissue engineering
610   $aWilson Disease
615  7$aBiology, life sciences
700   $aSpee$b Bart$4auth$01290161
702   $aVan der Laan$b Luc J.W$4auth
702   $aVerstegen$b Monique M. A$4auth
906   $aBOOK
912   $a9910367744303321
996   $aBioengineering Liver Transplantation$93021369
997   $aUNINA