LEADER 04082nam 2201057z- 450 001 9910367742003321 005 20210211 010 $a3-03921-777-1 035 $a(CKB)4100000010106297 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/45263 035 $a(oapen)doab45263 035 $a(EXLCZ)994100000010106297 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aDisease and the Hippo Pathway: Cellular and Molecular Mechanisms 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 online resource (226 p.) 311 08$a3-03921-776-3 330 $aThe Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tightly regulated, dysregulated Hippo pathway signaling drives the onset and progression of a range of diseases, including fibrosis and cancer. The molecular understanding of the Hippo pathway is rapidly evolving. This Special Issue contains ten articles contributed by established and up-and-coming Hippo pathway experts that, as a whole, provides an up-to-date overview of how dysregulated Hippo pathway activity is a common driver of specific diseases. The articles have a particular focus on the underlying molecular and cellular mechanisms that cause the Hippo pathway to go awry, and especially how this drives disease. The articles analyze disease-specific as well as common themes, which provides valuable insights into the fundamental molecular mechanisms in the dysfunctioning Hippo pathway, and thereby offer practical insights into potential future therapeutic intervention strategies. 517 $aDisease and the Hippo Pathway 606 $aBiology, life sciences$2bicssc 610 $aadaptive immunity 610 $aangiogenesis 610 $aanti-cancer therapy 610 $aautoimmunity 610 $acancer 610 $acancer immunity 610 $acastration resistance 610 $achromatin 610 $aECM 610 $aEMT 610 $aepigenetic 610 $afeedback loops 610 $afibroblasts 610 $afibrosis 610 $aG protein-coupled receptor 610 $aGPCR 610 $aHippo 610 $ahippo pathway 610 $aHippo pathway 610 $aHippo signalling 610 $ainnate immunity 610 $aLATS 610 $aLATS (large tumor suppressor kinase) 610 $aLATS1/2 610 $aLats2 610 $aMps one binder 610 $aMST 610 $aMST (mammalian STE20-like protein kinase) 610 $aMST1/2 610 $amyofibroblast 610 $an/a 610 $aNDR 610 $aperipheral nerve sheath tumor 610 $aphosphorylation 610 $aprostate cancer 610 $aprotein kinase 610 $aprotein-protein interactions 610 $aschwannoma 610 $asignal cross-talk 610 $asignal transduction 610 $askin cancer 610 $askin development 610 $astem cell 610 $astem cells 610 $aSTK38 610 $aSTRIPAK 610 $astructure biology 610 $aTaz 610 $aTAZ 610 $aTAZ (transcriptional co-activator with PDZ-binding motif) 610 $aTEAD 610 $atranscription 610 $atumorigenesis 610 $avascular mimicry 610 $awound healing 610 $aYap 610 $aYAP 610 $aYAP (yes-associated protein) 610 $aYAP/TAZ 610 $azebrafish 615 7$aBiology, life sciences 700 $aHansen$b Carsten Gram$4auth$01297549 906 $aBOOK 912 $a9910367742003321 996 $aDisease and the Hippo Pathway: Cellular and Molecular Mechanisms$93024533 997 $aUNINA